| T21615 |
Guanidinoethyl sulfonate
|
Taurocyamine |
Chloride channel
|
|
Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist. |
| T8268 |
6,2'-Dihydroxyflavone
|
|
GABA Receptor
|
|
6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| T21499 |
Dimebolin
|
Latrepirdine,Dimebon,Dimebone |
5-HT Receptor
|
|
Dimebolin (Latrepirdine) is a 5-HT6 antagonist. |
| T3917 |
Protopanaxatriol
|
20(R)-APPT,20(R)-Protopanaxatriol,(20R)-Protopanaxatriol |
PPAR
|
|
Protopanaxatriol (20(R)-APPT), a major ginseng constituent, is a novel PPARγ antagonist. |
| T19713 |
HHQ
|
2-heptylquinolin-4(1H)-one |
Others
|
|
HHQ (2-heptylquinolin-4(1H)-one) is a PqsR antagonist. |
| TJS0341 |
7-Amino-4-(trifluoromethyl)coumarin
|
Coumarin 151,AFC |
5-HT Receptor
|
|
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 (GALR2) antagonist. 7-Amino-4-(trifluorometh... |
| T0354 |
Canrenone
|
6,7-Dehydro-7α-desthioacetylspironolactone,SC9376,Aldadiene,RP-11614,SC14266 |
Glucocorticoid Receptor
,
Endogenous Metabolite
|
|
Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity. |
| TQ0197 |
Acenocoumarol
|
|
|
|
Acenocoumarol is a Vitamin K antagonist and used as an anticoagulant. |
| TN1519L |
(-)-Coclaurine hydrochloride
|
(-)-Coclaurine hydrochloride (486-39-5 Free base) |
AChR
|
|
(-)-Coclaurine hydrochloride is an antagonist of nAChRs isolated from Sarcopetalum harveyanum. |
| T7177 |
Capsazepine
|
|
Apoptosis
,
TRP/TRPV Channel
|
|
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is ... |
| T3S2100 |
(-)-Securinine
|
Securinine |
GABA Receptor
|
|
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. |
| T21504 |
γ-Linolenic Acid methyl ester
|
Methyl gamma-linolenate |
LTR
|
|
γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist. |
| TN1465 |
Cannabigerol
|
|
NOS
,
5-HT Receptor
,
ROS
|
|
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... |
| T8304 |
Anisodamine Hydrobromide
|
6-Hydroxyhyoscyamine |
Adrenergic Receptor
,
AChR
|
|
Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock. |
| T2751 |
Ginkgolide B
|
BN-52021 |
Apoptosis
,
PAFR
,
Endogenous Metabolite
|
|
Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba. |
| T1680 |
Tolazoline hydrochloride
|
Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride) |
Adrenergic Receptor
|
|
Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. |
| T0525 |
Flopropione
|
Phloropropiophenone |
5-HT Receptor
,
Transferase
|
|
Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist. |
| T3668 |
Galangin
|
Norizalpinin,3,5,7-Trihydroxyflavone |
ERK
,
P450
,
NF-κB
,
Autophagy
|
|
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. |
| T3379 |
Decanoic Acid
|
Decoic acid,CAPRIC ACID,Caprynic acid |
GluR
,
iGluR
|
|
Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist. |
| TQ0027 |
Transcrocetinate disodium
|
Disodium trans-crocetinate |
NMDAR
,
iGluR
|
|
Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor. |
| T5743 |
Gymnemagenin
|
|
Liver X Receptor
|
|
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity. |
| T2825 |
Cyclopamine
|
11-Deoxojervine |
Hedgehog/Smoothened
,
Endogenous Metabolite
,
Smo
|
|
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. |
| T2S1464 |
Thiocolchicoside
|
Thiocolchicine 2-glucoside analog,Coltramyl |
Others
,
GABA Receptor
|
|
Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece... |
| T1156 |
Palonosetron hydrochloride
|
RS 25259 197,Palonosetron HCl,RS 25259 |
5-HT Receptor
|
|
Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
| T21165 |
Pellitorine
|
AI3-19560,Pellitorin |
TRP/TRPV Channel
|
|
Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist. |
| T20884 |
Hydroxyzine
|
Hydroxyzine free base |
Histamine Receptor
|
|
Hydroxyzine (Hydroxyzine free base) is an antagonist of histamine H1-receptor. |
| T5776 |
Pimpinellin
|
|
Apoptosis
,
Anti-infection
|
|
Pimpinellin is a natural product that acts as antagonist of proteins with GABA receptor activity. |
| T2815 |
Puerarin
|
Kakonein |
5-HT Receptor
|
|
Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist. |
| T6S0109 |
Sipeimine
|
Kashmirine,Imperialine |
Others
|
|
1. Sipeimine (Kashmirine) has antiasthmatic effect, on tracheal M receptor antagonist. 2. Sipeimine can make Kaba cholinergic induced contraction of tracheal strips of the dose-response curve to the right. |
| T1186 |
Ifenprodil Tartrate
|
|
Potassium Channel
,
NMDAR
,
iGluR
|
|
Ifenprodil is a selective NMDA receptor (glutamate) antagonist. |
| T4429 |
Rauwolscine hydrochloride
|
Corynanthidine hydrochloride,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride |
Adrenergic Receptor
|
|
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes b... |
| T0970 |
Racanisodamine
|
Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine |
Adrenergic Receptor
,
AChR
|
|
Racanisodamine (7β-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock. |
| T21581L |
AC 187 Acetate
|
AC 187 Acetate (151804-77-2 Free base) |
Amylin Receptor
|
|
AC 187 Acetate is a potent antagonist of amylin receptor .AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. |
| T0268 |
Lobeline hydrochloride
|
α-Lobeline hydrochloride,L-Lobeline hydrochloride |
AChR
|
|
Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes. |
| T7939 |
Fingolimod
|
FTY-720A,FTY-720 |
S1P Receptor
,
PAK
,
LPL Receptor
|
|
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells). |
| T6648 |
Rotundine
|
Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine |
Dopamine Receptor
,
5-HT Receptor
|
|
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
| T2898 |
Andrographolide
|
Andrographis |
SARS-CoV
,
Influenza Virus
,
NF-κB
,
Autophagy
|
|
Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic. |
| TN1849 |
Kuwanon H
|
|
GPR
,
Bombesin Receptor
|
|
Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP. |
| T16535 |
Picrotoxinin
|
|
Chloride channel
,
GABA Receptor
|
|
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties. |
| T7060 |
Amantadine
|
1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine |
Others
|
|
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. |
| T22583 |
Arcaine sulfate
|
|
NMDAR
|
|
Arcaine sulfate is a NMDA antagonist. |
| T5S0273 |
Hypaphorine
|
Lenticin,Glyyunnanenine,Tryptophan Betaine |
Others
|
|
1. Hypaphorine (Lenticin) is an indole-3-acetic acid antagonist which specifically compete with indole-3-acetic acid in binding to the indole-3-acetic acid-binding site in plant peroxidases. |
| TN2247 |
Swertisin
|
|
Adenosine Receptor
|
|
Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, anti-inflammatory and antioxidant effects. |
| T10822 |
Cirsimarin
|
Cirsitakaoside |
Adenosine Receptor
|
|
Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 re... |
| T3865 |
Beta-Eudesmol
|
Beta-Selinenol |
TRP/TRPV Channel
,
AChR
|
|
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biologica... |
| TN7129 |
Methyl maslinate
|
Maslinic acid methyl ester,Crategolic acid methyl ester |
Adrenergic Receptor
|
|
|
| T3915 |
Ginsenoside Ro
|
Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V |
Calcium Channel
,
Reductase
,
Prostaglandin Receptor
|
|
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM. |
| T8373 |
6-Diazo-5-oxo-L-nor-Leucine
|
DON,L-6-Diazo-5-oxonorleucine,Diazooxonorleucine |
Influenza Virus
,
Glutaminase
,
Antibacterial
,
Antibiotic
|
|
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM). It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. |
| TN3695 |
Coniine hydrochloride
|
|
Others
|
|
Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system. |
| T15686 |
L-741626
|
3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole |
Dopamine Receptor
|
|
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively). |
