Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
説明 | OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
ターゲット&IC50 | SIRT2 (cell-free assay):751 μM, SIRT6 (cell-free assay):89 μM, SIRT1 (cell-free assay):1578 μM |
In vitro | OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6. |
キナーゼ試験 | In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured . |
細胞研究 | BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours. |
別名 | SIRT6-IN-1 |
分子量 | 366.32 |
分子式 | C19H14N2O6 |
CAS No. | 887686-02-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 68 mg/mL (185.6 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
OSS_128167 887686-02-4 Chromatin/Epigenetic DNA Damage/DNA Repair Microbiology/Virology HBV Sirtuin SIRT6 deacetylase TNF-α SIRT6-IN-1 immune antiviral inhibit PPARα H3K9 acetylation anti-cancer Hepatitis B virus Inhibitor diabetes GLUT-1 chemosensitization inhibitor