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T80947 |
Tri-GalNAc-COOH (acetylation)
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LYTACs
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Tri-GalNAc-COOH acetylation represents the acetylated derivative of tri-galactosamine (tri-GalNAc-COOH), utilized in the synthesis of lysosome targeting chimeras (LYTAC). |
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T6421 |
BRD73954
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HDAC
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BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. |
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T11563 |
Histone Acetyltransferase Inhibitor II
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|
Epigenetic Reader Domain
,
Histone Acetyltransferase
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Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells. |
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T11807 |
L002
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Others
,
Histone Acetyltransferase
,
STAT
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L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ... |
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T13996 |
1-Naphthohydroxamic acid
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|
HDAC
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1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d... |
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T5347 |
CXD101
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CXD-101 |
HDAC
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CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II |
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T14991 |
CMS-121
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CMS121 |
Acetyl-CoA Carboxylase
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CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotect... |
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T1818 |
Tenovin-6
|
Tenovin 6 |
Dehydrogenase
,
Sirtuin
,
Autophagy
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Tenovin-6 is a p53 transcriptional activity agonist. |
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T1919 |
Tenovin-1
|
Tenovin 1 |
Mdm2
,
Dehydrogenase
,
Sirtuin
,
p53
,
Autophagy
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|
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. |
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T23820 |
BRD32048
|
BRD-32048,BRD 32048 |
DNA/RNA Synthesis
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BRD32048 is the ETV1 transcription factor oncoprotein inhibitor. |
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T8480 |
Tenovin-6 Hydrochloride
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|
Dehydrogenase
,
Sirtuin
,
HDAC
,
p53
,
Autophagy
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Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |
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T4328 |
OSS_128167
|
SIRT6-IN-1 |
HBV
,
Sirtuin
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OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
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T60065 |
WAY-118959-A
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Microtubule Associated
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WAY-118959-A is a potential microtubule acetylation inhibitor. |
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T23917 |
CRT-0105950
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CRT 0105950 |
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CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells. |
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T0538 |
3-Methylindolin-2-one
|
3-Methyloxindole,3-Methyl-2-oxindole |
Others
,
Endogenous Metabolite
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3-Methylindolin-2-one (3-Methyloxindole) is a reactant for O-acetylation reactions, enantioselective α-amination reactions and for aldol reactions with glyoxal derivatives and more. |
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T28543 |
RK-9123016
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RK9123016,RK 9123016 |
Sirtuin
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RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer ce... |
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T16409 |
OSMI-1
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Others
,
Acyltransferase
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OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans. |
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T19717 |
Cyclo-L-Trp-L-Trp
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Antifungal
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Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones. |
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T77697 |
BML-278
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BML278,BML 278 |
Sirtuin
,
Histone Methyltransferase
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BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind... |
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T9320 |
YK-3-237
|
B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid |
Sirtuin
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YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca... |
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T4353 |
SR-18292
|
SR 18292 |
Autophagy
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SR-18292 is an inhibitor of PPAR gamma coactivator-1α (PGC-1α), which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes. |
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T24131 |
HDAC3-IN-T247
|
HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247 |
Histone Demethylase
,
Antiviral
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HDAC3-IN-T247 (HDAC3 inhibitor T247) is a selective and potent histone deacetylase 3 (HDAC3) inhibitor with anticancer and antiviral activities.HDAC3-IN-T247 induces NF-κB acetylation in human colon cancer HCT116 cells i... |
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T27083 |
Crebinostat
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Epigenetic Reader Domain
,
Histone Acetyltransferase
,
HDAC
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Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct... |
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T24793 |
SIRT6-IN-5
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SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5 |
Sirtuin
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SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, ... |
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T23095 |
NU 9056
|
NU9056 |
Histone Acetyltransferase
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NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines. |
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T21792 |
CGP 3466B maleate
|
Omigapil (Maleate),Omigapil maleate |
Apoptosis
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CGP 3466B maleate (Omigapil maleate) is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil male... |
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T25176 |
BRD2577
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BRD-2577,BRD 2577 |
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BRD2577 is an HDAC inhibitor, by suppressing multiple HDAC enzymes and modulating acetylation levels in cells. |
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T69879 |
Bavarostat
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Bavarostata is a highly brain penetrant HDAC6 inhibitor (IC50=60nM). Bavarostat exhibits excellent HDAC6 selectivity (>80-fold over all other Zn-containing HDAC paralogues), modulates tubulin acetylation selectively over... |
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T23916 |
CRT-0105446
|
CRT0105446 |
|
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CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells. |
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T24132 |
HDAC3-IN-T326
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HDAC3 inhibitor-T326,T326,HDAC3 IN T326,HDAC3 inhibitor T326,HDAC3INT326 |
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HDAC3-IN-T326 is a potent and selective HDAC3 inhibitor that acts by increasing NF-κB acetylation and activating HIV gene expression in latent HIV-infected cells. |
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T30292 |
BAMF
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BAMF is a chemical reagent used in the chemical modification of proteins, mainly in the acetylation process. |
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T20364 |
Aspartylglutamate
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Asp-glu |
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Aspartylglutamate is a precursor molecule. When it upon acetylation to N-acetyl-aspartyl-glutamate (NAAG) is used as a metabotropic glutamate mGlu receptor agonist. |
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T24998 |
AC-93253 iodide
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AC93253 iodide |
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AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4. |
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T39580 |
Histone H3 (23-34)
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Histone H3 (23-34) |
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Histone H3 (23-34) is a peptide consisting of amino acid residues 23 to 34 of the histone H3 protein. This peptide specifically includes lysine residues at positions 23 and 27, which can undergo methylation and acetylati... |
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T72503 |
Antitubulin agent 1
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Antitubulin Agents-1, an antitubulin agent, disrupts microtubules (Microtubule/Tubulin) and enhances α-tubulin acetylation, exhibiting anticancer effects. |
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TP1836 |
BMf-BH3
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|
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BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetyl... |
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T36576 |
Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
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Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) |
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Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44... |
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T35818 |
CAY10669
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|
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CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY106... |
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T62916 |
GEM144
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GEM144 is a potent, orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC 11. GEM144 induces p53 acetylation, activates p21, blocks the cell cycle in G1/S phase and induces apoptosis. |
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T79586 |
3′-Acetate-ATP
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|
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3’-Acetate-ATP, an analogue of ATP and its acetylation product, exhibits maximum ultraviolet absorption at 259 nm in neutral aqueous solutions. It impedes nucleic acid polymerization [1]. |
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T35825 |
Trichostatin C
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Trichostatin C is a glycosylated derivative of trichostatin A , the antifungal antibiotic that reversibly inhibits histone deacetylase. Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate i... |
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T62917 |
MIR002
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|
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MIR002 is a potent, orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC 11 with significant in vivo antitumor activity. p53 acetylation, p21 activation, cell cycle arrest in G1/S phase, and apoptosis induct... |
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T39799 |
S2157
|
S2157 |
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S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound tri... |
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T61433 |
HDAC1-IN-5
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|
|
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HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 an... |
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T82342 |
Gamma-Glutamyl Transferase-IN-2
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Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits both antifungal and antibacterial properties by targeting glutamyltransferase. Its mode of action includes inducing reactive o... |
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T62708 |
HDAC-IN-37
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HDAC-IN-37 is a potent inhibitor of HDAC, acting on HDAC1 (IC50: 0.0551 μM), HDAC3 (IC50: 1.24 μM), HDAC8 (IC50: 0.948 μM) and HDAC6 (IC50: 34.2 μM). HDAC-IN-37 is able to slowly induce histone acetylation. HDAC-IN-37 pr... |
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T76158 |
Phosphate acetyltransferase
|
|
|
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Phosphate acetyltransferase, a transferase enzyme utilized in biochemical research, catalyzes the reversible acetylation of CoA from acetyl-P, yielding acetyl-CoA and inorganic phosphate. This process is integral to acet... |
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T82343 |
Gamma-Glutamyl Transferase-IN-1
|
|
|
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Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting glutamyltransferase. Its mechanism of action involves inducing the accumu... |
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T73796 |
Acetyl coenzyme A lithium
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Acetyl-coenzyme A (Acetyl-CoA) lithium, a membrane-impermeant central metabolic intermediate, is integral to the TCA cycle and oxidative phosphorylation. It regulates cellular mechanisms by serving as the sole donor of a... |
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T36577 |
K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
|
K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) |
|
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Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker.... |
