Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
説明 | Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. |
ターゲット&IC50 | Cathepsin K (rabbit):1 nM, Cathepsin K (human):0.2 nM |
In vitro | In rats, Odanacatib (10 mg/kg) exhibits efficient clearance (Cl: 2 mL kg-1 min-1), low volume of distribution (Vdss: 1.1 L kg-1), a half-life (T1/2) of 6 hours, and oral bioavailability (F) of 8%. |
In vivo | Odanacatib exhibits inhibitory activity towards human cathepsin K (IC50=0.2 nM) and rabbit cathepsin K (IC50=1 nM). It also demonstrates effectiveness in human cell assays with an IC50 value of 5 nM. |
別名 | MK-0822 |
分子量 | 525.56 |
分子式 | C25H27F4N3O3S |
CAS No. | 603139-19-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (177 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Odanacatib 603139-19-1 Proteases/Proteasome Cysteine Protease MK 0822 MK0822 Inhibitor Cathepsin inhibit MK-0822 inhibitor