Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 9,500 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
200 mg | 在庫あり | ¥ 14,500 | |||
500 mg | 在庫あり | ¥ 22,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). |
In vitro | Omeprazole transiently alters the kinetic properties of parietal cells in rabbits, leading to premature cell death and expedited growth. By inhibiting H(+)-K(+)-ATPase, omeprazole enhances the clearance of degenerative changes and macrophage-mediated removal of parietal cells, as well as promoting the increase of progenitor cells at the apical ridge. |
In vivo | Omeprazole diminishes the activation of osteoclasts in vitro, while enhancing the activation of osteoblasts, leading to osteosclerosis-like effects to some extent. In human hepatocellular carcinoma cells, omeprazole induces the transcription of reporter genes through dioxin receptor elements recognized by ligand-activated aryl hydrocarbon receptors. It effectively induces the expression of cytochrome P4501A1 mRNA in primary human hepatocytes, but this induction is not detected in mouse primary hepatocytes. Omeprazole significantly suppresses the basal natural killer (NK) activity in splenocytes (SC) from untreated CD2F1 mice. It exerts rapid and robust effects on various types of cytotoxic lymphocytes, ranging from the inhibition of cytotoxicity to irreversible cellular damage. Furthermore, omeprazole notably inhibits the cytotoxicity of all types of effector cells after 30 minutes of incubation. |
別名 | Losec, Prilosec, H 16868, Antra |
分子量 | 345.42 |
分子式 | C17H19N3O3S |
CAS No. | 73590-58-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1eq. HCl: 17.3 mg/mL (50 mM)
DMSO: 34.5 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Omeprazole 73590-58-6 Autophagy Membrane transporter/Ion channel Metabolism Microbiology/Virology Phospholipase Proton pump Antibacterial inhibit Inhibitor Losec Prilosec Bacterial Proton Pump H 16868 H-16868 H16868 Antra inhibitor