Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 52,500 | |||
50 mg | 在庫あり | ¥ 79,000 | |||
100 mg | 在庫あり | ¥ 114,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. |
ターゲット&IC50 | CK1ε:32 nM, CKIδ:711 nM |
In vitro | PF-4800567 shows inhibitory activity against CK1ε and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 (32 nM) has little effect on the circadian clock [1]. |
In vivo | PF-4800567 (100 mg/kg, s.c.) is rapidly absorbed and distributed in plasma and brain of mice [1]. |
分子量 | 359.81 |
分子式 | C17H18ClN5O2 |
CAS No. | 1188296-52-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (166.76 mM)
You can also refer to dose conversion for different animals. 詳細
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PF-4800567 1188296-52-7 Metabolism Stem Cells Casein Kinase inhibit PF4800567 PF 4800567 Inhibitor inhibitor