Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
説明 | PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively. |
ターゲット&IC50 | EGFR:0.14 nM(ki) |
別名 | PF 6274484 |
分子量 | 372.78 |
分子式 | C18H14ClFN4O2 |
CAS No. | 1035638-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (174.36 mM)
You can also refer to dose conversion for different animals. 詳細
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PF-6274484 1035638-91-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR oxidation PF 6274484 autophosphorylation signaling Epidermal growth factor receptor HER1 protein ErbB-1 inhibit kinase cysteine PF6274484 Inhibitor inhibitor