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Search Results for " signaling "

ターゲット

TGF-beta/Smad

933

阻害剤

255

天然化合物

1974

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T7799	BMP signaling agonist sb4	SB 4	TGF-beta/Smad
	BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)		TGF-beta/Smad
T1810	Purmorphamine	Shh Signaling Antagonist VI	Hedgehog/Smoothened , Smo , Autophagy
	Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.		Hedgehog/Smoothened , Smo , Autophagy
T82063	Integrin signaling inhibitor, mP13
	Integrin Signaling Inhibitor mP13 is a compound that impedes both inside-out and outside-in integrin-mediated signaling processes, such as fibrinogen binding, platelet adhesion, and clot retraction [1].
T14898	CCG-63808		GTPase
	CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.		GTPase
T14897	CCG-63802		GTPase
	CCG-63802 is a reversible inhibitor of the regulator of G-protein signaling (RGS) protein and has the greatest potency at RGS4.		GTPase
T12246	CB-103		Gamma-secretase
	CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.		Gamma-secretase
T8418	DCLK1-IN-1		Others
	DCLK1-IN-1 is a selective and in vivo-compatible chemical probe of the DCLK1 kinase domain .		Others
T21658	ARN14974		Others
	ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM[1].		Others
T15485	HJC0197		cAMP , Ras
	HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).		cAMP , Ras
T6434	CCG-50014	CCG 50014	GTPase
	CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.		GTPase
T4304	Azoramide		Apoptosis , PERK
	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.		Apoptosis , PERK
T8452	Dantrolene		Others
	Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.		Others
T8843	APS6-45		MAPK , Ras
	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.		MAPK , Ras
T4022	QS11	QS 11	GTPase
	QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r...		GTPase
T38163	ML-148		Dehydrogenase
	ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostagla...		Dehydrogenase
T10904	CWP232228		Wnt/beta-catenin
	CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t...		Wnt/beta-catenin
T4400	DIM-C-pPhOH	CDIM8	Apoptosis , Others
	DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi...		Apoptosis , Others
T5486	RU.521	RU320521	DNA , cGAS
	RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.		DNA , cGAS
T23027	MRT-10		Hedgehog/Smoothened
	MRT-10 is a Smoothened (Smo) receptor antagonist.		Hedgehog/Smoothened
T11438	GNE-1858		Others , MAPK
			Others , MAPK
T22396	PF-6274484	PF 6274484	EGFR
	PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and ...		EGFR
T1986L	Atopaxar Hydrobromide		Protease-activated Receptor
	Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.		Protease-activated Receptor
T28073	MLS1547	MLS000051547,MLS 1547,MLS-1547	Dopamine Receptor
	MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assa...		Dopamine Receptor
T21826	TC-E 5003	NSC 30176	Histone Methyltransferase
	TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.		Histone Methyltransferase
T1986	Atopaxar	E5555,ER-172594-00	Protease-activated Receptor
	Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.		Protease-activated Receptor
T1900	LDN-212854	LDN212854,BMP Inhibitor III	ALK , TGF-beta/Smad
	LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.		ALK , TGF-beta/Smad
T0948	Adrenalone hydrochloride	Adrenalone HCl	Adrenergic Receptor
	Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc...		Adrenergic Receptor
T6626	PF-3758309	PF-309,PF-03758309,PF 3758309	Apoptosis , PAK
	PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.		Apoptosis , PAK
T4230	PF-3758309 hydrochloride	PF-03758309 hydrochloride	Apoptosis , PAK
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...		Apoptosis , PAK
T3280	Clodronate disodium tetrahydrate	clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium	IL Receptor , TNF
	Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.		IL Receptor , TNF
T9105	NF-κB-IN-1	1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-	IκB/IKK , NF-κB
	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir...		IκB/IKK , NF-κB
T28281	OXSI-2	OXSI 2,Syk Inhibitor	Syk
	OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.		Syk
T9137	SN-011	[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING
	SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.		STING
T24797	SK609 HCl	SK-609 HCl,SK609 hydrochloride,SK 609 HCl,SK 609 hydrochloride,SK-609 hydrochloride
	SK609 HCl is a selective dopamine D3 receptor agonist. It also has atypical signaling properties.
T24159	IHR-1	IHR 1	Smo
	IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.		Smo
T60803	Wnt/β-catenin agonist 4		Wnt/beta-catenin
	Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.		Wnt/beta-catenin
T67866	YW2036		Wnt/beta-catenin
	YW2036 is an inhibitor of Wnt signaling pathway.		Wnt/beta-catenin
T6322	Copanlisib	BAY 80-6946	Apoptosis , PI3K
	Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c...		Apoptosis , PI3K
T3502	C29		TLR
	C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.		TLR
T40220L	TRV055 acetate	TRV055 acetate (25849-90-5 Free base)	RAAS
	TRV055 acetate is a ligand of angiotensin II type 1 receptor and stimulates cellular Gq-mediated signaling.		RAAS
T26296	Triparanol	MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis , Hedgehog/Smoothened
	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan...		Apoptosis , Hedgehog/Smoothened
T77603	WAY-313170		PDE
	WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.		PDE
T3075	FLI-06	FLI 06	Gamma-secretase
	FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).		Gamma-secretase
T60644	SJ000063181		TGF-beta/Smad
	SJ000063181 is a potent activator of BMP signaling, exhibiting an EC50 of ≤1 μM. It serves as a valuable chemical probe for BMP signaling analysis, owing to its ability to penetrate zebrafish embryos.		TGF-beta/Smad
T60011	HS220		MAPK
	HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.		MAPK
T60055	Chromeceptin	2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile	Akt , IGF-1R , mTOR
	Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.		Akt , IGF-1R , mTOR
T2413	FH535		Wnt/beta-catenin , PPAR
	FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.		Wnt/beta-catenin , PPAR
T72021	SU 5616	WAY-608241
	SU 5616 (WAY-608241) regulates abnormal cell proliferation and modulates tyrosine kinase signaling.
T7830	Windorphen		Wnt/beta-catenin
	Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.		Wnt/beta-catenin
T15633	JW74		Wnt/beta-catenin
	JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).		Wnt/beta-catenin

Compounds

BMP signaling agonist sb4

T7799

Synonym: SB 4

Target: TGF-beta/Smad

Purmorphamine

T1810

Synonym: Shh Signaling Antagonist VI

Target: Hedgehog/Smoothened, Smo, Autophagy

Integrin signaling inhibitor, mP13

Target: Gamma-secretase

Target: Apoptosis, PERK

Target: Dehydrogenase

CWP232228

T10904

Synonym:

Target: Wnt/beta-catenin

DIM-C-pPhOH

T4400

Synonym: CDIM8

Target: Apoptosis, Others

Target: Hedgehog/Smoothened

Atopaxar Hydrobromide

T1986L

Synonym:

Target: Protease-activated Receptor

MLS1547

T28073

Synonym: MLS000051547,MLS 1547,MLS-1547

Target: Dopamine Receptor

TC-E 5003

T21826

Synonym: NSC 30176

Target: Histone Methyltransferase

Atopaxar

T1986

Synonym: E5555,ER-172594-00

Target: Protease-activated Receptor

LDN-212854

T1900

Synonym: LDN212854,BMP Inhibitor III

Target: ALK, TGF-beta/Smad

Adrenalone hydrochloride

T0948

Synonym: Adrenalone HCl

Target: Adrenergic Receptor

PF-3758309

T6626

Synonym: PF-309,PF-03758309,PF 3758309

Target: Apoptosis, PAK

PF-3758309 hydrochloride

T4230

Synonym: PF-03758309 hydrochloride

Target: Apoptosis, PAK

Clodronate disodium tetrahydrate

T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium

Target: IL Receptor, TNF

NF-κB-IN-1

T9105

Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

Target: IκB/IKK, NF-κB

OXSI-2

T28281

Synonym: OXSI 2,Syk Inhibitor

Target: Syk

SN-011

T9137

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Target: STING

SK609 HCl

T24797

Synonym: SK-609 HCl,SK609 hydrochloride,SK 609 HCl,SK 609 hydrochloride,SK-609 hydrochloride

Wnt/β-catenin agonist 4

T60803

Synonym:

Target: Wnt/beta-catenin

YW2036

T67866

Synonym:

Target: Wnt/beta-catenin

Copanlisib

T6322

Synonym: BAY 80-6946

Target: Apoptosis, PI3K

Synonym: TRV055 acetate (25849-90-5 Free base)

Target: RAAS

Triparanol

T26296

Synonym: MER-29,NSC 65345,NSC-65345,NSC65345

Target: Apoptosis, Hedgehog/Smoothened

Target: Gamma-secretase

SJ000063181

T60644

Synonym:

Target: TGF-beta/Smad

Synonym: 2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile

Target: Akt, IGF-1R, mTOR

FH535

T2413

Synonym:

Target: Wnt/beta-catenin, PPAR

Target: Wnt/beta-catenin

JW74

T15633

Synonym:

Target: Wnt/beta-catenin

カタログ番号	製品名	別名	ターゲット
T4S2126	Ginkgetin		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 ...		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
T3912	Saikosaponin B1		Others
	Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.		Others
T0760	Cholesterol	Cholesterin,Cholesteryl alcohol	Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
	Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...		Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
TN6739	Angoline	6-Methoxyldihydrochelerythrine	IL Receptor , STAT
	Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can...		IL Receptor , STAT
T14854	Caerulomycin A	Cerulomycin,Caerulomycin	Antifungal
	Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound. Which induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antif...		Antifungal
T4S0544	Furanodienone		Apoptosis , HER
	1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependen...		Apoptosis , HER
T2789	Scutellarin	Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt , HIV Protease , STAT
	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signal...		Akt , HIV Protease , STAT
T3008	Lawsone methyl ether	2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone	Apoptosis , Antibacterial , Antifungal
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s...		Apoptosis , Antibacterial , Antifungal
TN1143	1-O-Acetyl britannilactone		NF-κB , COX
	1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR-Src-FAK signaling.		NF-κB , COX
TQ0312	Sphingomyelin		Endogenous Metabolite
	Sphingomyelin is a natural sphingolipid that existed in animal cell membranes. It implicates the regulation of transmembrane signaling.		Endogenous Metabolite
TQ0065	Pseudobufarenogin	ψ-Bufarenogin	Others
	Pseudobufarenogin (ψ-Bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.		Others
T6S0619	Pachymic acid	3-O-Acetyltumulosic acid	ERK , Akt
	Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.		ERK , Akt
TN1916	Matairesinol		ATPase , p38 MAPK , ROS
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.		ATPase , p38 MAPK , ROS
T8229	5,7,3',4'-Tetramethoxyflavone		Antibacterial , Parasite , Antifungal
	5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflamm...		Antibacterial , Parasite , Antifungal
T0421	I-Inositol	Inositol,myo-Inositol,meso-Inositol	Endogenous Metabolite
	i-Inositol (myo-Inositol) is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation.		Endogenous Metabolite
T3890	Verbenalin	Verbenalol β-D-glucopyranoside,Verbenaloside,Verbenalol glucoside,Cornin	Others
	Verbenalin (Verbenaloside) induces angiogenesis via a programmed PI3K/Akt/eNOS/VEGF signaling axis.		Others
TN1058	Pelargonidin chloride		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
TN2346	Mogrol		ERK , AMPK , STAT
	Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.		ERK , AMPK , STAT
T3676	Sesamol	1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol	Apoptosis , AMPK
	Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig...		Apoptosis , AMPK
TN1836	Kudinoside D		LDL , AMPK , PPAR
	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.		LDL , AMPK , PPAR
T6S1740	Nardosinone		Others
	1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...		Others
T2862	Desaminotyrosine	Phloretate,3-(4-Hydroxyphenyl)propanoic acid,Hydro-p-coumaric acid,3-(4-Hydroxyphenyl)propionic acid,Phloretic acid	Others , Influenza Virus , Endogenous Metabolite
	Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) is a microbially associated metabolite. Desaminotyrosine protects from influenza through augmentation of type I interferon signaling.		Others , Influenza Virus , Endogenous Metabolite
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T3896	Shanzhiside methyl ester		Glucagon Receptor
	Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling.		Glucagon Receptor
TN2081	Maohuoside A		MAPK
	Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.		MAPK
T6856	Halofuginone	Tempostatin,empostatin,RU-19110	Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
TN1833	Karacoline		NF-κB
	Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.		NF-κB
T6S0107	Peimine	Wanpeinine A,Dihydroisoimperialine,Verticine	Others
	1. Peimine (Wanpeinine A) has good anti-inflammatory effects in vivo. 2. Peimine is an inhibitor to inhibit LPS-induced production of inflammatory cytokines by blocking the MAPKs and NF-κB signaling pathway.		Others
T5793	Britannin		Apoptosis , AMPK , Autophagy
	Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.		Apoptosis , AMPK , Autophagy
T3913	Saikosaponin D		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
T13803	N-Oleoyl glycine		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
	N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
T2956	Cedryl acetate	Cedrol acetate,Cedranyl acetate	Antifungal
	Cedryl acetate (Cedranyl acetate) , an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions.		Antifungal
TMA0507	Tomatidine		NF-κB , JNK , Autophagy
	Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.		NF-κB , JNK , Autophagy
T2896	Alantolactone	helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor	Apoptosis , STAT , TGF-beta/Smad
	Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3...		Apoptosis , STAT , TGF-beta/Smad
TN1079	Deoxyelephantopin		NF-κB
	Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling		NF-κB
T5057	DL-O-Phosphoserine	DL-2-Amino-3-hydroxypropanoic acid 3-phosphate,O-PHOSPHO-L-SERINE,DL-SOP	Others , Endogenous Metabolite
	DL-O-Phosphoserine (DL-SOP), a normal metabolite in human biofluid, is an ester of serine and phosphoric acid. Serine is one of three amino acid residues that are commonly phosphorylated by kinases during cell signaling ...		Others , Endogenous Metabolite
T3330	Trans-Trimethoxyresveratrol	trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene	Reactive Oxygen Species
	trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy...		Reactive Oxygen Species
T83321	4-Demethyldeoxypodophyllotoxin		Chk
	4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.		Chk
TQ0183	Narciclasine	Lycoricidinol	ROCK
	Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.		ROCK
T7982	3,6-Dihydroxyflavone		Others
	3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.		Others
T5729	L-quebrachitol		Wnt/beta-catenin
	L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.		Wnt/beta-catenin
TN1445	Bisabolangelone		p38 MAPK , MAPK
	Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.		p38 MAPK , MAPK
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
TN1077	Taraxerol	Skimmiol,Alnulin	Apoptosis , NF-κB
	Taraxerol(Alnulin) is an anti-inflammatory and anticancer compound derived from dandelion.Taraxerol reduces acute inflammation and induces apoptosis by inhibiting the NF-κB signaling pathway.		Apoptosis , NF-κB
TN1892	Lusianthridin		Others , c-Myc
	Lusianthridin is a natural product from Dendrobium venustum. Lusianthridin exhibits anti-migratory property at nontoxic concentrations. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signali...		Others , c-Myc
T3S0335	Soyasaponin Bb	Soyasaponin I	NF-κB , Caspase
	1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signa...		NF-κB , Caspase
T19397	L-Methionine sulfoxide	H-Met(O)-OH	Endogenous Metabolite
	L-Methionine sulfoxide (H-Met(O)-OH) (H-Met(O)-OH) is a metabolite of Methionine. (H-Met(O)-OH) modulates oxidative stress and purinergic signaling parameters, and induces M1/classical macrophage polarization.		Endogenous Metabolite
T0906	Salinomycin	Procoxacin	Wnt/beta-catenin , Antibacterial
	Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosph...		Wnt/beta-catenin , Antibacterial
T14008	2,2,5,7,8-Pentamethyl-6-Chromanol	PMC	Androgen Receptor
	2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.		Androgen Receptor
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天然物製品

Ginkgetin

T4S2126

Synonym:

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Synonym: Cholesterin,Cholesteryl alcohol

Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR

Brevilin A

T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Angoline

TN6739

Synonym: 6-Methoxyldihydrochelerythrine

Target: IL Receptor, STAT

Caerulomycin A

T14854

Synonym: Cerulomycin,Caerulomycin

Target: Apoptosis, HER

Scutellarin

T2789

Synonym: Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide

Target: Akt, HIV Protease, STAT

Lawsone methyl ether

T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone

Target: Apoptosis, Antibacterial, Antifungal

1-O-Acetyl britannilactone

Target: Endogenous Metabolite

Pseudobufarenogin

TQ0065

Synonym: ψ-Bufarenogin

Target: Others

Pachymic acid

T6S0619

Synonym: 3-O-Acetyltumulosic acid

Target: ATPase, p38 MAPK, ROS

5,7,3',4'-Tetramethoxyflavone

T8229

Synonym:

Target: Antibacterial, Parasite, Antifungal

i-Inositol

T0421

Synonym: Inositol,myo-Inositol,meso-Inositol

Target: Endogenous Metabolite

Verbenalin

T3890

Synonym: Verbenalol β-D-glucopyranoside,Verbenaloside,Verbenalol glucoside,Cornin

Target: Others

Pelargonidin chloride

TN1058

Synonym:

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Mogrol

TN2346

Synonym:

Target: ERK, AMPK, STAT

Sesamol

T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol

Target: Apoptosis, AMPK

Kudinoside D

TN1836

Synonym:

Target: LDL, AMPK, PPAR

Synonym: Phloretate,3-(4-Hydroxyphenyl)propanoic acid,Hydro-p-coumaric acid,3-(4-Hydroxyphenyl)propionic acid,Phloretic acid

Target: Others, Influenza Virus, Endogenous Metabolite

Arnicolide D

TN1405

Synonym:

Target: Akt, Caspase, PI3K, STAT, mTOR

Shanzhiside methyl ester

T3896

Synonym:

Target: Glucagon Receptor

Synonym: Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Synonym: Wanpeinine A,Dihydroisoimperialine,Verticine

Target: Apoptosis, AMPK, Autophagy

Saikosaponin D

T3913

Synonym:

Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT

N-Oleoyl glycine

T13803

Synonym:

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Cedryl acetate

T2956

Synonym: Cedrol acetate,Cedranyl acetate

Target: NF-κB, JNK, Autophagy

Alantolactone

T2896

Synonym: helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor

Target: Apoptosis, STAT, TGF-beta/Smad

Synonym: DL-2-Amino-3-hydroxypropanoic acid 3-phosphate,O-PHOSPHO-L-SERINE,DL-SOP

Target: Others, Endogenous Metabolite

trans-Trimethoxyresveratrol

T3330

Synonym: trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene

Target: Reactive Oxygen Species

4-Demethyldeoxypodophyllotoxin

Synonym: Lycoricidinol

Target: Wnt/beta-catenin

Bisabolangelone

TN1445

Synonym:

Target: p38 MAPK, MAPK

Gigantol

TL0008

Synonym:

Target: Wnt/beta-catenin, Glucosidase

Taraxerol

TN1077

Synonym: Skimmiol,Alnulin

Target: Apoptosis, NF-κB

Lusianthridin

TN1892

Synonym:

Target: Others, c-Myc

Soyasaponin Bb

T3S0335

Synonym: Soyasaponin I

Target: NF-κB, Caspase

L-Methionine sulfoxide

T19397

Synonym: H-Met(O)-OH

Target: Endogenous Metabolite

Salinomycin

T0906

Synonym: Procoxacin

Target: Wnt/beta-catenin, Antibacterial

2,2,5,7,8-Pentamethyl-6-Chromanol

T14008

Synonym: PMC

Target: Androgen Receptor

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01174	DKK1 Protein, Rhesus, Recombinant (N256Q, His)	Rhesus	HEK293
	Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ...
TMPH-00221	Agouti-signaling Protein, Bovine, Recombinant (His)	Bovine	Baculovirus
	Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) an...
TMPY-04811	DKK1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ...
TMPY-01121	DKK3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 p...
TMPY-00775	DKK1 Protein, Human, Recombinant (His)	Human	HEK293
	Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ...
TMPY-04413	IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04753	IRE1 Protein, Human, Recombinant (aa 465-977)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04918	CNPY4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CNPY4 belongs to the canopy family. CNPY4 interacts with toll-like receptor 4 (TLR4) and plays a role in the regulation of the cell surface expression of TLR4. Toll-like receptors (TLRs) recognize microbial products and ...
TMPY-01175	DKK1 Protein, Rhesus, Recombinant (N256Q, mFc)	Rhesus	HEK293
	Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ...
TMPY-03179	CNPY4 Protein, Human, Recombinant (His)	Human	HEK293
	CNPY4 belongs to the canopy family. CNPY4 interacts with toll-like receptor 4 (TLR4) and plays a role in the regulation of the cell surface expression of TLR4. Toll-like receptors (TLRs) recognize microbial products and ...
TMPY-05797	DKK1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ...
TMPY-06377	DKK3 Protein, Human, Recombinant	Human	HEK293
	DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 p...
TMPY-03667	SLAM/CD150 Protein, Rat, Recombinant (His)	Rat	HEK293
	CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is exp...
TMPY-00627	SLAM/CD150 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is exp...
TMPY-05005	CNPY3 Protein, Human, Recombinant (His)	Human	HEK293
	CNPY3 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 28.5 kDa. Accession number: A0A7U3JW12
TMPY-00138	CNPY3 Protein, Human, Recombinant (hFc)	Human	HEK293
	CNPY3 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 53.7 kDa. Accession number: Q9BT09-1
TMPY-05479	DKK1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ...
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His)	Human	HEK293
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such...
TMPY-03261	CNPY2 Protein, Human, Recombinant (His)	Human	HEK293
	CNPY2 is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. CNPY2 enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light cha...
TMPH-00909	ASIP Protein, Human, Recombinant (GST & His)	Human	E. coli
	ASIP Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPJ-00223	SLAMF1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in...
TMPY-01016	SLAM/CD150 Protein, Human, Recombinant (His)	Human	HEK293
	CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is exp...
TMPY-00596	CNPY3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CNPY3 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 28.6 kDa. Accession number: Q9DAU1-1
TMPY-00226	CNPY3 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	CNPY3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 53.9 kDa. Accession number: Q9DAU1-1
TMPJ-00226	SLAMF1 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, an...
TMPY-02924	RGS1 Protein, Human, Recombinant (His)	Human	E. coli
	RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type I diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization o...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, plac...
TMPJ-01345	TCblR Protein, Human, Recombinant (His)	Human	Human Cells
	CD320 antigen is also known as 8D6 antigen，FDC-signaling molecule 8D6，Transcobalamin receptor and 8D6A. It is a single-pass type I membrane protein and containing two LDL-receptor class A domains. CD320 has been recentl...
TMPJ-01344	TCblR Protein, Human, Recombinant (hFc)	Human	Human Cells
	CD320 antigen is also known as 8D6 antigen，FDC-signaling molecule 8D6，Transcobalamin receptor and 8D6A. It is a single-pass type I membrane protein and containing two LDL-receptor class A domains. CD320 has been recentl...
TMPH-01189	CISH Protein, Human, Recombinant (GST)	Human	E. coli
	CISH Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPY-04058	RGS5 Protein, Human, Recombinant (His)	Human	E. coli
	RGS5 is a member of the RGS superfamily and acts as a negative regulator of heterotrimeric G protein-mediated signalling through G protein-coupled receptors (GPCRs). The regulator of G-protein signaling (RGS) proteins ha...
TMPJ-00455	SLAMF5 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based ...
TMPJ-01129	SMAD1 Protein, Human, Recombinant (GST)	Human	E. coli
	SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcripti...
TMPJ-00229	SLAMF5 Protein, Human, Recombinant (His)	Human	Human Cells
	SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 a...
TMPJ-00228	SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 a...
TMPJ-01086	CD244 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Natural killer cell receptor 2B4 (2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like d...
TMPJ-00359	SLAMF3 Protein, Human, Recombinant (His)	Human	Human Cells
	SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like trunca...
TMPJ-01154	SLAMF3 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	CD229(SLAMF3) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature mouse CD229 consists of a 406 aa extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set doma...
TMPY-05081	Notch 1 Protein, Human, Recombinant (hFc)	Human	HEK293
	NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair...
TMPY-02115	R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)	Human	HEK293
	R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in devel...
TMPY-00834	IGF1R/CD221 Protein, Human, Recombinant (His)	Human	HEK293
	The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPY-01147	R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)	Human	HEK293
	RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the r...
TMPY-03197	R-Spondin 1/RSPO1 Protein, Mouse, Recombinant (His)	Mouse	CHO
	RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the r...
TMPY-02361	VEGFR2/KDR Protein, Human, Recombinant (His)	Human	HEK293
	VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ...
TMPY-03626	R-Spondin 1/RSPO1 Protein, Human, Recombinant	Human	CHO
	RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the r...
TMPJ-01463	IL-2 Protein, Human, Recombinant (E. coli)	Human	E. coli
	Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or m...
TMPY-00776	DLL4 Protein, Human, Recombinant (hFc)	Human	HEK293
	Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-01337	DLL4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPJ-01464	IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)	Human	Human Cells
	Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or m...
TMPY-00835	IGFBP-3 Protein, Human, Recombinant (His)	Human	HEK293
	The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory...
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DKK1 Protein, Rhesus, Recombinant (N256Q, His)

TMPY-01174

Species: Rhesus

Expression System: HEK293

Agouti-signaling Protein, Bovine, Recombinant (His)

TMPH-00221

Species: Bovine

Expression System: Baculovirus

DKK1 Protein, Mouse, Recombinant (His)

TMPY-04811

Species: Mouse

Expression System: HEK293

DKK3 Protein, Mouse, Recombinant (His)

TMPY-01121

Species: Mouse

Expression System: HEK293

DKK1 Protein, Human, Recombinant (His)

TMPY-00775

Species: Human

Expression System: HEK293

IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)

TMPY-04413

Species: Human

Expression System: Baculovirus-Insect Cells

IRE1 Protein, Human, Recombinant (aa 465-977)

TMPY-04753

Species: Human

Expression System: Baculovirus-Insect Cells

CNPY4 Protein, Mouse, Recombinant (His)

TMPY-04918

Species: Mouse

Expression System: HEK293

DKK1 Protein, Rhesus, Recombinant (N256Q, mFc)

TMPY-01175

Species: Rhesus

Expression System: HEK293

CNPY4 Protein, Human, Recombinant (His)

TMPY-03179

Species: Human

Expression System: HEK293

DKK1 Protein, Rat, Recombinant (His)

TMPY-05797

Species: Rat

Expression System: HEK293

DKK3 Protein, Human, Recombinant

TMPY-06377

Species: Human

Expression System: HEK293

SLAM/CD150 Protein, Rat, Recombinant (His)

TMPY-03667

Species: Rat

Expression System: HEK293

SLAM/CD150 Protein, Rat, Recombinant (hFc)

TMPY-00627

Species: Rat

Expression System: HEK293

CNPY3 Protein, Human, Recombinant (His)

TMPY-05005

Species: Human

Expression System: HEK293

CNPY3 Protein, Human, Recombinant (hFc)

TMPY-00138

Species: Human

Expression System: HEK293

DKK1 Protein, Human, Recombinant (hFc)

TMPY-05479

Species: Human

Expression System: HEK293

WISP1/CCN4 Protein, Human, Recombinant (His)

TMPY-00950

Species: Human

Expression System: HEK293

CNPY2 Protein, Human, Recombinant (His)

TMPY-03261

Species: Human

Expression System: HEK293

ASIP Protein, Human, Recombinant (GST & His)

TMPH-00909

Species: Human

Expression System: E. coli

SLAMF1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00223

Species: Human

Expression System: Human Cells

SLAM/CD150 Protein, Human, Recombinant (His)

TMPY-01016

Species: Human

Expression System: HEK293

CNPY3 Protein, Mouse, Recombinant (His)

TMPY-00596

Species: Mouse

Expression System: HEK293

CNPY3 Protein, Mouse, Recombinant (hFc)

TMPY-00226

Species: Mouse

Expression System: HEK293

SLAMF1 Protein, Mouse, Recombinant (His)

TMPJ-00226

Species: Mouse

Expression System: Human Cells

RGS1 Protein, Human, Recombinant (His)

TMPY-02924

Species: Human

Expression System: E. coli

SOCS3 Protein, Human, Recombinant (His & Trx)

TMPY-02194

Species: Human

Expression System: E. coli

TCblR Protein, Human, Recombinant (His)

TMPJ-01345

Species: Human

Expression System: Human Cells

TCblR Protein, Human, Recombinant (hFc)

TMPJ-01344

Species: Human

Expression System: Human Cells

CISH Protein, Human, Recombinant (GST)

TMPH-01189

Species: Human

Expression System: E. coli

RGS5 Protein, Human, Recombinant (His)

TMPY-04058

Species: Human

Expression System: E. coli

SLAMF5 Protein, Mouse, Recombinant (His)

TMPJ-00455

Species: Mouse

Expression System: Human Cells

SMAD1 Protein, Human, Recombinant (GST)

TMPJ-01129

Species: Human

Expression System: E. coli

SLAMF5 Protein, Human, Recombinant (His)

TMPJ-00229

Species: Human

Expression System: Human Cells

SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00228

Species: Human

Expression System: Human Cells

CD244 Protein, Mouse, Recombinant (His)

TMPJ-01086

Species: Mouse

Expression System: Human Cells

SLAMF3 Protein, Human, Recombinant (His)

TMPJ-00359

Species: Human

Expression System: Human Cells

SLAMF3 Protein, Mouse, Recombinant (His)

TMPJ-01154

Species: Mouse

Expression System: Human Cells

Notch 1 Protein, Human, Recombinant (hFc)

TMPY-05081

Species: Human

Expression System: HEK293

R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)

TMPY-02115

Species: Human

Expression System: HEK293

IGF1R/CD221 Protein, Human, Recombinant (His)

TMPY-00834

Species: Human

Expression System: HEK293

R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)

TMPY-01147

Species: Human

Expression System: HEK293

R-Spondin 1/RSPO1 Protein, Mouse, Recombinant (His)

TMPY-03197

Species: Mouse

Expression System: CHO

VEGFR2/KDR Protein, Human, Recombinant (His)

TMPY-02361

Species: Human

Expression System: HEK293

R-Spondin 1/RSPO1 Protein, Human, Recombinant

TMPY-03626

Species: Human

Expression System: CHO

IL-2 Protein, Human, Recombinant (E. coli)

TMPJ-01463

Species: Human

Expression System: E. coli

DLL4 Protein, Human, Recombinant (hFc)

TMPY-00776

Species: Human

Expression System: HEK293

DLL4 Protein, Mouse, Recombinant (His)

TMPY-01337

Species: Mouse

Expression System: HEK293

IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)

TMPJ-01464

Species: Human

Expression System: Human Cells

IGFBP-3 Protein, Human, Recombinant (His)

TMPY-00835

Species: Human

Expression System: HEK293

--------- More ---------

カタログ番号	製品名
L2600	Neuronal Signaling Compound Library	2540 compounds
	A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
L3800	NF-κB Signaling Compound Library	729 compounds
	A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
L1310	Cytoskeletal Signaling Pathway Compound Library	759 compounds
	A unique collection of 759 cytoskeleton-related compounds, can be used for HTS and HCS；
L8500	HIF-1 Signaling Pathway Compound Library	1336 compounds
	A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L4300	Wnt/Hedgehog/Notch Compound Library	237 compounds
	A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
L3600	Cytokine Inhibitor Library	604 compounds
	A unique collection of 604 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
L3700	JAK-STAT Compound Library	252 compounds
	A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;
L2000	Inhibitor Library	8328 compounds
	A unique collection of 8328 inhibitors for research in cell signaling, high throughput screening (HTS) and high content screening (HCS) for new drugs;
L1400	MAPK Inhibitor Library	365 compounds
	A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
L1300	PI3K-AKT-mTOR Compound Library	420 compounds
	A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
L4660	Anti-Nervous System Disease Library	1246 compounds
	Well-chosen 1246 compounds with unique structures targeting nervous system;
L8700	Ferroptosis Compound Library	779 compounds
	A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
L2193	Anti-Liver Cancer Compound Library	1787 compounds
	1787 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies.
L4100	TGF-beta/Smad Compound Library	184 compounds
	A unique collection of 184 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
L7000	Bioactive Lipid Compound Library	385 compounds
	A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, ...
L1510	Nuclear Receptor Compound Library	531 compounds
	A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;
L1120	AMPK-Targeted Compound Library	80 compounds
	80 well-chosen unique AMPK-targeted small molecules；
L7900	Osteogenesis Compound Library	317 compounds
	A unique collection of 317 osteogenesis related compounds for high throughput and high content screening;
L7700	Neural Regeneration Compound Library	524 compounds
	A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L8110	Reprogramming Compound Library	1813 compounds
	A unique collection of 1813 reprogramming signaling pathway-related bioactive small molecule compounds for high-throughput, high-content screening.
L2195	Anti-Prostate Cancer Compound Library	2070 compounds
	2070 compounds associated with prostate cancer that can be used for high-throughput and high-content screening.
L8000	Stem Cell Differentiation Compound Library	1197 compounds
	A unique collection of 1197 stem cell differentiation signaling targeted compounds for high throughput and high content screening;
L2191	Anti-Breast Cancer Compound Library	1939 compounds
	A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study；
L4020	NO PAINS Compound Library	9384 compounds

L2200	Tyrosine Kinase Inhibitor Library	1016 compounds
	A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L2400	Endocrinology-Hormone Compound Library	784 compounds
	A unique collection of 784 compounds targeting endocrine system for high throughput screening (HTS) and high content screening (HCS) for new drugs;
L1580	GPCR Compound Library Plus	338 compounds
	Well-chosen 338 GPCR targeting compounds with unique structures;
L1600	Kinase Inhibitor Library	2700 compounds
	A unique collection of 2700 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
L1610	FDA-Approved Kinase Inhibitor Library	263 compounds
	A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L2150	Anti-Cancer Drug Library	3080 compounds
	A unique collection of 3080 anticancer drugs for high throughput screening (HTS) and high content screening (HCS);
L2160	Anti-Cancer Active Compound Library	3188 compounds
	A unique collection of 3188 compounds with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);
L2120	Anti-Cancer Clinical Compound Library	2545 compounds
	A unique collection of 2545 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS);
L2100	Anti-Cancer Compound Library	7234 compounds
	A unique collection of 7234 compounds with anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);
L2110	Anti-Cancer Approved Drug Library	1779 compounds
	A unique collection of 1779 approved anti-cancer drugs for high throughput screening (HTS) and high content screening (HCS);
L2190	Anti-Lung Cancer Compound Library	1702 compounds
	A unique collection of 1702 compounds with anti-lung cancer therapeutic activity or targeting lung cancer’s major signaling pathways, can be used for anti-lung cancer drug discovery and mechanism study；
L2180	Anti-Cancer Compound Library Plus	1468 compounds
	Well-chosen 1468 anti-tumor compounds with unique structures;
L6750	PBCRBS Traditional Chinese Medicine Compound Library	580 compounds
	A unique collection of 580 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis.
L1110	Microtubule-Targeted Compound Library	142 compounds
	A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS;
L7200	Calcium Channel Compound Library	140 compounds
	A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening;
L3300	Histamine & Melatonin Receptor-Targeted Compound Library	153 compounds
	A unique collection of 153 compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS) for new drugs;
L2194	Anti-Colorectal Cancer Compound Library	1545 compounds
	1545 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening.
L2550	Glutamine Metabolism Compound Library	565 compounds
	A unique collection of 565 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...
L9700	Endoplasmic Reticulum Stress Compound Library	193 compounds
	A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
L4700	Immunology/Inflammation Compound Library	4720 compounds
	A unique collection of 4720 anti-inflammation compounds effective for high throughput screening and high content screening.
L5300	Mitochondria-Targeted Compound Library	812 compounds
	A unique collection of 812 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
L2610	Neurotransmitter Receptor Compound Library	1513 compounds
	A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；
L2540	Gut Microbial Metabolite Library	607 compounds
	A unique collection of 607 gut microbial metabolites which can be used for HTS and HCS;
L9840	Anti-Alzheimer's Disease Compound Library	986 compounds
	A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.
L6740	Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library	382 compounds
	A collection of 382 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies.
L9600	Peptide Compound Library	791 compounds
	791 peptides can be used in peptide drug development and signaling transduction and mechanism study;