Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 g | 在庫あり | ¥ 11,500 | |||
10 g | 在庫あり | ¥ 13,500 | |||
25 g | 在庫あり | ¥ 16,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties. |
In vitro | Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] |
In vivo | The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] |
植物由来 |
別名 | INO 495, NSC 20262 |
分子量 | 268.23 |
分子式 | C10H12N4O5 |
CAS No. | 58-63-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (205.05 mM)
H2O: 43 mg/mL (160.3 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Inosine 58-63-9 GPCR/G Protein Immunology/Inflammation Metabolism Neuroscience ROS Adenosine Receptor Endogenous Metabolite Inhibitor INO495 metabolism inhibit human INO 495 P1 receptor antinociceptive adenosine disease NSC 20262 INO-495 metabolite neuroprotective nucleoside antihyperalgesic NSC20262 NSC-20262 immunomodulatory antiallodynic Parkinson's inhibitor