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ターゲット

cell cycle arrest Arrestin Others DNA/RNA Synthesis

405

阻害剤

天然化合物

117

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T8873	Bractoppin		Others , DNA/RNA Synthesis
	Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activi...		Others , DNA/RNA Synthesis
T11960	MBM-55		GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase

T4470	Pyridostatin TFA		DNA/RNA Synthesis
	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.		DNA/RNA Synthesis
T6515	Go6976	Gö 6976	PKC
	Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.		PKC
T21331	SAR-020106		Chk
	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.		Chk
T14066	9-ING-41		Apoptosis , GSK-3 , Autophagy
	9-ING-41 is a glycogen synthase kinase-3 inhibitor.		Apoptosis , GSK-3 , Autophagy
T23133	Pentamidine		Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T22461	YKL-5-124		CDK
	YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...		CDK
T15012	Crolibulin	EPC2407	Microtubule Associated
	Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.		Microtubule Associated
T36816	S-trityl-L-Cysteine	STLC	Kinesin
	S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ...		Kinesin
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T1899	Pyridostatin	RR82,Pyridostatin Trifluoroacetate Salt	DNA/RNA Synthesis
	Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres.		DNA/RNA Synthesis
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T1862	PR-619	PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis , DUB , Autophagy
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).		Apoptosis , DUB , Autophagy
T16156	MT 63-78		Apoptosis , AMPK , mTOR
	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...		Apoptosis , AMPK , mTOR
T21714	BMS453	BMS 453,BMS-189453	Retinoid Receptor
	BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.		Retinoid Receptor
T6019	Volasertib	BI 6727	Apoptosis , PLK
	Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).		Apoptosis , PLK
T13416	ZX-29		ALK
	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.		ALK
T1654	Pentamidine isethionate	Pentamidine isethionate salt,Pentamidine diisethionate	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T4134	OTS514 hydrochloride	OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))	Apoptosis , TOPK
	OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).		Apoptosis , TOPK
T23132	Pentamidine dihydrochloride	MP-601205 dihydrochloride	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T10898	Samuraciclib hydrochloride	ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis , CDK
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...		Apoptosis , CDK
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T2241	Alisertib	MLN 8237	Apoptosis , Aurora Kinase , Autophagy
	Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.		Apoptosis , Aurora Kinase , Autophagy
T2170	SKF-96365 hydrochloride	SKF96365	Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T4134L	OTS514	OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis , TOPK
	OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen...		Apoptosis , TOPK
T15183	Dynarrestin		Hedgehog/Smoothened
	Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. It inhibits dynein 1-driven microtubule gliding in vitro pl...		Hedgehog/Smoothened
T12006	Metarrestin	ML246	DNA/RNA Synthesis
	Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (...		DNA/RNA Synthesis
T10343	AOH1160	N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide	Apoptosis , DNA/RNA Synthesis
	AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication.		Apoptosis , DNA/RNA Synthesis
T2425	KPT185	KPT-185,KPT 185	CRM1
	KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.		CRM1
T22305	Dexrazoxane	ICRF-187	Others
	Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.		Others
T6844	GGTI298 Trifluoroacetate	GGTI 298,GGTI 298 TFA salt	Apoptosis , Transferase , Ras
	GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.		Apoptosis , Transferase , Ras
T2615	Flavopiridol hydrochloride	Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl	HIV Protease , CDK , Autophagy
	Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of ...		HIV Protease , CDK , Autophagy
T27579	ICL-CCIC-0019	ICL CCIC 0019	AChR
	ICL-CCIC-0019 is an inhibitor of choline kinase alpha (ChoKα). ICL-CCIC-0019 induces G1 arrest, endoplasmic reticulum stress, and apoptosis of cancer cell lines.		AChR
T9712	PF07104091	PF-07104091	CDK
	PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.		CDK
T34262	RAPTA-C		Apoptosis
	RAPTA-C induces EAC cell cycle arrest and apoptosis via the mitochondrial and p53-JNK pathways, and can be used in the study of breast and ovarian cancer.		Apoptosis
T4189	4-Oxofenretinide	3-Keto fenretinide	cell cycle arrest
	4-Oxofenretinide (3-Keto fenretinide) , a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis.		cell cycle arrest
T17187	TZ9		Apoptosis , E1/E2/E3 Enzyme
	TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.		Apoptosis , E1/E2/E3 Enzyme
T77667	PI3Kδ-IN-16		Apoptosis , PI3K
	PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.		Apoptosis , PI3K
T10268	AGX51		Others
			Others
T19699	Triciribine phosphate	TCN-P,VD 002,VQD-002	Apoptosis , Akt
	Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascularization, and can be used in the study of leukemia.		Apoptosis , Akt
T77647	Tubulin polymerization-IN-43		Apoptosis , Microtubule Associated
	Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell c...		Apoptosis , Microtubule Associated
T61588	AGN 192870		Apoptosis , Retinoid Receptor
	AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.		Apoptosis , Retinoid Receptor
T3485	Probimane	AT-2153,MM-159	Others
	Probimane (AT-2153) had Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation in human tumor cell lines with MST-16.		Others
T60564	PI3K/Akt/mTOR-IN-2		Apoptosis , Akt , PI3K , mTOR
	PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI3K/Akt/mTOR-IN-2 exhibits anticancer activity and induces c...		Apoptosis , Akt , PI3K , mTOR
T19831	Sodium Oxamate	oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO	Apoptosis , Dehydrogenase , CDK
	Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.		Apoptosis , Dehydrogenase , CDK
TP1430	DTP3 TFA (1809784-29-9 free base)	DTP3 TFA	Others
	DTP3 TFA (1809784-29-9 free base) (DTP3 TFA) is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.		Others

Compounds

Bractoppin

T8873

Synonym:

Target: Others, DNA/RNA Synthesis

MBM-55

T11960

Synonym:

Target: GSK-3, MAPK, DYRK, Akt, Chk, Bcr-Abl, CDK, S6 Kinase, Aurora Kinase

Pyridostatin TFA

T4470

Synonym:

Target: DNA/RNA Synthesis

Target: Apoptosis, GSK-3, Autophagy

Pentamidine

T23133

Synonym:

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

SC144

T6207

Synonym:

Target: Apoptosis, Interleukin

Target: Microtubule Associated

Target: Akt, PKA, S6 Kinase, Autophagy

Pyridostatin

T1899

Synonym: RR82,Pyridostatin Trifluoroacetate Salt

Target: DNA/RNA Synthesis

Batabulin

T10460

Synonym: T138067

Target: Apoptosis, Microtubule Associated

PR-619

T1862

Synonym: PR 619,2,6-Diamino-3,5-dithiocyanopyridine

Target: Apoptosis, DUB, Autophagy

MT 63-78

T16156

Synonym:

Target: Apoptosis, AMPK, mTOR

BMS453

T21714

Synonym: BMS 453,BMS-189453

Target: Retinoid Receptor

Volasertib

T6019

Synonym: BI 6727

Target: Apoptosis, PLK

Pentamidine isethionate

T1654

Synonym: Pentamidine isethionate salt,Pentamidine diisethionate

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

KRCA-0008

T2641

Synonym: KRCA 0008,KRCA0008

Target: Apoptosis, Pim

OTS514 hydrochloride

T4134

Synonym: OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))

Target: Apoptosis, TOPK

Pentamidine dihydrochloride

T23132

Synonym: MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Samuraciclib hydrochloride

T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

CCT128930 hydrochloride

T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Alisertib

T2241

Synonym: MLN 8237

Target: Apoptosis, Aurora Kinase, Autophagy

SKF-96365 hydrochloride

T2170

Synonym: SKF96365

Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy

OTS514

T4134L

Synonym: OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514

Target: Apoptosis, TOPK

Dynarrestin

T15183

Synonym:

Target: Hedgehog/Smoothened

Metarrestin

T12006

Synonym: ML246

Target: DNA/RNA Synthesis

AOH1160

T10343

Synonym: N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide

Target: Apoptosis, DNA/RNA Synthesis

KPT185

T2425

Synonym: KPT-185,KPT 185

GGTI298 Trifluoroacetate

T6844

Synonym: GGTI 298,GGTI 298 TFA salt

Target: Apoptosis, Transferase, Ras

Flavopiridol hydrochloride

T2615

Synonym: Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl

Target: HIV Protease, CDK, Autophagy

ICL-CCIC-0019

T27579

Synonym: ICL CCIC 0019

Synonym: 3-Keto fenretinide

Target: cell cycle arrest

TZ9

T17187

Synonym:

Target: Apoptosis, E1/E2/E3 Enzyme

PI3Kδ-IN-16

T77667

Synonym:

Target: Apoptosis, PI3K

Triciribine phosphate

T19699

Synonym: TCN-P,VD 002,VQD-002

Target: Apoptosis, Akt

Tubulin polymerization-IN-43

T77647

Synonym:

Target: Apoptosis, Microtubule Associated

AGN 192870

T61588

Synonym:

Target: Apoptosis, Retinoid Receptor

Probimane

T3485

Synonym: AT-2153,MM-159

Target: Apoptosis, Akt, PI3K, mTOR

Sodium Oxamate

T19831

Synonym: oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO

Target: Apoptosis, Dehydrogenase, CDK

DTP3 TFA (1809784-29-9 free base)

TP1430

Synonym: DTP3 TFA

Target: Others

カタログ番号	製品名	別名	ターゲット
TQ0089	Juglanin		Apoptosis , JNK , Autophagy
	Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.		Apoptosis , JNK , Autophagy
TN2069	Picrocrocin		Apoptosis
	Picrocrocin is a natural product		Apoptosis
T5724	Neogambogic acid	neo-gambogic acid	Apoptosis , Others , Antibacterial
	Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell li...		Apoptosis , Others , Antibacterial
TWP2911	Thymidine	5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others , DNA/RNA Synthesis , Endogenous Metabolite
	1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.		Others , DNA/RNA Synthesis , Endogenous Metabolite
T21351	Maytansine	NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine	Microtubule Associated , Antibiotic
	Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.		Microtubule Associated , Antibiotic
TN1019	Beta-mangostin	β-Mangostin	Apoptosis , Antibacterial , Parasite
	Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo...		Apoptosis , Antibacterial , Parasite
T3322	Trans-Chalcone	Chalcone,Cinnamophenone,Chalkone	Apoptosis , Others , Antifungal , Fatty Acid Synthase
	trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.		Apoptosis , Others , Antifungal , Fatty Acid Synthase
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T1508	Decitabine	Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA Methyltransferase
	Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis...
T6S0234	Toosendanin		Others
	1. Toosendanin possesses hepatotoxicity. 2. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. 3. Toosendanin i...		Others
T6S2038	Ziyuglycoside II		Apoptosis , Antioxidant , Reactive Oxygen Species
	1. Ziyuglycoside II has anti-inflammation and antioxidation properties. 2. Ziyuglycoside II has antibiosis, and homeostasis properties. 3. Ziyuglycoside II has anticancer, and antitumor properties against gastric cancer ...		Apoptosis , Antioxidant , Reactive Oxygen Species
T3909	Pulsatilla saponin D	Hederacolchiside A,SB365	Apoptosis , Others
	Pulsatilla saponin D (Hederacolchiside A) has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer, and it inhibits cell growth via cell cycle arrest and apopt...		Apoptosis , Others
T3774	Gracillin		cell cycle arrest
	Gracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent. Gracillin can be selected as lead compounds for the development of new d...		cell cycle arrest
T2336	Vitamin K2	Menatetrenone	Endogenous Metabolite
	Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signaling of certain tyrosine kinases, thereby affecting several...		Endogenous Metabolite
T1272	Cytarabine	Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , HSV
	Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
T0190	Vinorelbine	KW-2307 base	Microtubule Associated
	Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.		Microtubule Associated
TMS0484	Episyringaresinol 4'-O-β-D-glncopyranoside	(-)-Syringaresinol 4-O-β-D-glucopyranosi	Others
	Episyringaresinol 4'-O-β-D-glncopyranoside ((-)-Syringaresinol 4-O-β-D-glucopyranosi) inhibits the proliferation of human promyelocytic HL-6 cells through G(1) arrest and induction of apoptosis, may be a potential chemot...		Others
T0968	Paclitaxel	Taxol,NSC 125973	Apoptosis , Microtubule Associated , Autophagy
	Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.		Apoptosis , Microtubule Associated , Autophagy
TN1658	Ganoderenic acid D		Apoptosis , Others
	Ganoderenic acid D is a natural product isolated from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D induces cell cycle arrest and apoptosis and inhibits the proliferation of cancer cells.		Apoptosis , Others
TJS0487	(-)-Syringaresinol	DL-Syringaresinol,Lirioresinol b	Others
	(-)-Syringaresinol (DL-Syringaresinol) is derived from the stems of Annona Montana. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis and posses...		Others
T4S1540	Myrislignan		Apoptosis , NF-κB
	Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induc...		Apoptosis , NF-κB
T3008	Lawsone methyl ether	2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone	Apoptosis , Antibacterial , Antifungal
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s...		Apoptosis , Antibacterial , Antifungal
T2S0886	Terrestrosin D		Apoptosis , Others
	Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of action...		Apoptosis , Others
T2S0820	Karanjin		Apoptosis , AMPK
	Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arre...		Apoptosis , AMPK
T22455	Vindesine sulfate	DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS	Others
	Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule...		Others
TN1244	3'-Demethylnobiletin		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
	3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ...		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
TN1620	Eriocalyxin B		Apoptosis , cAMP , NF-κB , STAT
	Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh...		Apoptosis , cAMP , NF-κB , STAT
TN1222	26-Deoxyactein	27-Deoxyactein,23-epi-26-Deoxyactein	NOS , CDK , NO Synthase
	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can in...		NOS , CDK , NO Synthase
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T5S0527	Rhodojaponin III		Others
	1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodoja...		Others
T3386	Kaempferitrin	Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside	cell cycle arrest , Glucokinase , IGF-1R
	Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...		cell cycle arrest , Glucokinase , IGF-1R
TN1804	Isosilybin A		Apoptosis , Tyrosinase , PPAR , ABC
	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angio...		Apoptosis , Tyrosinase , PPAR , ABC
T3426	Bacoside A		MMP , Others , TNF , Dopamine Receptor , NOS , ROS
	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidat...		MMP , Others , TNF , Dopamine Receptor , NOS , ROS
T3S0081	Oxypeucedanin	(+-)-Oxypeucedanin,Oxypeucadanin	Potassium Channel
	1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke...		Potassium Channel
T3398	Icaritin	Anhydroicaritin,Cycloicaritin	Apoptosis , JAK , STAT , Autophagy
	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...		Apoptosis , JAK , STAT , Autophagy
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T4S1615	Sanggenon C	Sanggenone C	NF-κB
	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO pro...		NF-κB
T2938	(E/Z)-Polydatin	Polydatin,(E/Z)-Piceid	Phospholipase
	(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be det...		Phospholipase
T2966	Beta-Sitosterol	Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost	Apoptosis , Lipase , Endogenous Metabolite
	Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun...		Apoptosis , Lipase , Endogenous Metabolite
T3339	Sophoridine	5-Epidihydrosophocarpine,Dihydro-5-episophocarpine	Apoptosis , Topoisomerase
	Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity ...		Apoptosis , Topoisomerase
T37067	9-hydroxy Stearic Acid		HDAC
	9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (...		HDAC
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
TN1141	Isodeoxyelephantopin		NF-κB , Reactive Oxygen Species , Autophagy
	Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibit...		NF-κB , Reactive Oxygen Species , Autophagy
T32055	Hemiasterlin	NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin
	Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation.
TN5371	8-Hydroxy-ar-turmerone
	8-Hydroxy-ar-turmerone may exhibit antitumor activity against breast cancer cells via cell death and cell cycle arrest.
TN4154	Gomisin L1		Others
	(-)-Gomisin L1 induces G2/M arrest and apoptosis in human ovarian cancer cells.		Others
TN6511	Tessaric acid
	Tessaric acid has antifeedant and allelochemical effects. Tessaric acid derivatives induce G/M cell cycle arrest in human solid tumor cell lines.
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天然物製品

Juglanin

TQ0089

Synonym:

Target: Apoptosis, JNK, Autophagy

Synonym: neo-gambogic acid

Target: Apoptosis, Others, Antibacterial

Thymidine

TWP2911

Synonym: 5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Maytansine

T21351

Synonym: NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine

Target: Microtubule Associated, Antibiotic

Beta-mangostin

TN1019

Synonym: β-Mangostin

Target: Apoptosis, Antibacterial, Parasite

trans-Chalcone

T3322

Synonym: Chalcone,Cinnamophenone,Chalkone

Target: Apoptosis, Others, Antifungal, Fatty Acid Synthase

(S)-10-Hydroxycamptothecin

T2764

Synonym: 10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Acacetin

T3981

Synonym: 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Decitabine

T1508

Synonym: Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA Methyltransferase

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Pulsatilla saponin D

T3909

Synonym: Hederacolchiside A,SB365

Target: Apoptosis, Others

Gracillin

T3774

Synonym:

Target: cell cycle arrest

Vitamin K2

T2336

Synonym: Menatetrenone

Target: Endogenous Metabolite

Cytarabine

T1272

Synonym: Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Vinorelbine

T0190

Synonym: KW-2307 base

Target: Microtubule Associated

Episyringaresinol 4'-O-β-D-glncopyranoside

TMS0484

Synonym: (-)-Syringaresinol 4-O-β-D-glucopyranosi

Target: Others

Paclitaxel

T0968

Synonym: Taxol,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy

Ganoderenic acid D

TN1658

Synonym:

Target: Apoptosis, Others

(-)-Syringaresinol

TJS0487

Synonym: DL-Syringaresinol,Lirioresinol b

Target: Apoptosis, NF-κB

Lawsone methyl ether

T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone

Target: Apoptosis, Antibacterial, Antifungal

Terrestrosin D

T2S0886

Synonym:

Target: Apoptosis, Others

Karanjin

T2S0820

Synonym:

Target: Apoptosis, AMPK

Vindesine sulfate

T22455

Synonym: DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS

Target: LDL, NF-κB, Integrin, Lipoxygenase, DNA/RNA Synthesis

Eriocalyxin B

TN1620

Synonym:

Target: Apoptosis, cAMP, NF-κB, STAT

26-Deoxyactein

TN1222

Synonym: 27-Deoxyactein,23-epi-26-Deoxyactein

Target: NOS, CDK, NO Synthase

Crebanine

T2S2215

Synonym:

Target: Apoptosis, Others, Akt

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside

Target: cell cycle arrest, Glucokinase, IGF-1R

Isosilybin A

TN1804

Synonym:

Target: Apoptosis, Tyrosinase, PPAR, ABC

Bacoside A

T3426

Synonym:

Target: MMP, Others, TNF, Dopamine Receptor, NOS, ROS

Oxypeucedanin

T3S0081

Synonym: (+-)-Oxypeucedanin,Oxypeucadanin

Target: Potassium Channel

Icaritin

T3398

Synonym: Anhydroicaritin,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

2-Methoxyestradiol

T2220

Synonym: NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Sanggenon C

T4S1615

Synonym: Sanggenone C

Target: NF-κB

(E/Z)-Polydatin

T2938

Synonym: Polydatin,(E/Z)-Piceid

Target: Phospholipase

Beta-Sitosterol

T2966

Synonym: Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

Sophoridine

T3339

Synonym: 5-Epidihydrosophocarpine,Dihydro-5-episophocarpine

Target: Apoptosis, Topoisomerase

9-hydroxy Stearic Acid

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Oroxylin A

T6S1315

Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Isodeoxyelephantopin

TN1141

Synonym:

Target: NF-κB, Reactive Oxygen Species, Autophagy

Hemiasterlin

T32055

Synonym: NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin

Target:

8-Hydroxy-ar-turmerone

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPY-02150	GADD45A Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulatio...
TMPJ-00366	GAS6 Protein, Human, Recombinant (hFc)	Human	Human Cells
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds...
TMPY-02238	MAD2L1 Protein, Human, Recombinant (His)	Human	E. coli
	Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 famil...
TMPJ-00692	GAS7 Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting ...
TMPY-03655	GADD45G Protein, Human, Recombinant	Human	E. coli
	GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G re...
TMPJ-00365	GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	Human Cells
	Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signa...
TMPJ-00907	GADD45A Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some ...
TMPJ-00700	GADD45B Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of g...
TMPJ-00711	GADD45G Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 Υ (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G interacts with various proteins whose transcript...
TMPJ-00603	TL1A Protein, Mouse, Recombinant	Mouse	E. coli
	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor ...
TMPY-00365	GALNT7 Protein, Human, Recombinant (His)	Human	HEK293
	GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either ...
TMPY-00981	ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK)	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-01601	AXL Protein, Human, Recombinant (His)	Human	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-01142	ICAM-1/CD54 Protein, Human, Recombinant (His)	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-05017	ICAM-1/CD54 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-01349	ICAM-1/CD54 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-04774	ALK-2/ACVR1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
TMPY-01167	E-Selectin/CD62E Protein, Human, Recombinant (His)	Human	HEK293
	E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involv...
TMPY-01196	CD3D Protein, Human, Recombinant (His)	Human	HEK293
	T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heter...
TMPH-01658	MAGEA4 Protein, Human, Recombinant (His)	Human	HEK293
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-02234	TMPRSS11A Protein, Human, Recombinant (His)	Human	E. coli
	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
TMPH-01659	MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)	Human	E. coli
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-00604	CDTA Protein, E. coli, Recombinant (His)	E. coli	E. coli
	CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for ...
TMPH-00605	CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)	E. coli	E. coli
	Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arres...
TMPH-02111	SRP72 Protein, Human, Recombinant (GST)	Human	E. coli
	Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might intera...
TMPJ-01097	ZBTB17 Protein, Human, Recombinant (His)	Human	E. coli
	Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific g...
TMPH-03415	Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)	RVFV	E. coli
	Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool...
TMPH-01520	HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc)	HIV-1	E. coli
	During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPH-01519	HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)	HIV-1	E. coli
	During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPK-00517	GAS6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of ...
TMPK-00660	AMIGO2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BE...
TMPK-01072	AMIGO2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BE...
TMPK-00497	ICAM-1/CD54 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-...
TMPK-00872	ICAM-1/CD54 Protein, Canine, Recombinant (His)	Canine	HEK293
	Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-...
TMPY-01561	PIG3 Protein, Human, Recombinant (His)	Human	E. coli
	Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of ca...
TMPY-03048	PRAP1 Protein, Human, Recombinant (mFc)	Human	HEK293
	PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPY-03076	PRAP1 Protein, Human, Recombinant (His)	Human	HEK293
	PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPH-01650	PRAME Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination a...
TMPH-01651	PRAME Protein, Human, Recombinant (His)	Human	Yeast
	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination a...
TMPJ-01372	Cornulin Protein, Human, Recombinant (His)	Human	E. coli
	Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter...
TMPH-02200	TXNIP Protein, Human, Recombinant (B2M & His)	Human	in vitro E. coli expression system
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPH-02929	TXNIP Protein, Mouse, Recombinant (His)	Mouse	Yeast
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPJ-00307	BLK Protein, Human, Recombinant (His)	Human	E. coli
	Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling...
TMPH-00900	Human adenovirus C serotype 5 Early E1A protein (His & SUMO)	HAdV-5	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01781	NSMCE3 Protein, Human, Recombinant (His)	Human	E. coli
	Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohe...
TMPH-02454	Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (E. coli, His)	MeV	E. coli
	Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a ...
TMPY-03068	HEPACAM2 Protein, Rat, Recombinant (His)	Rat	HEK293
	HEPACAM2 (HEPACAM Family Member 2) is a Protein Coding gene. This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abno...
TMPH-02453	Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (His)	MeV	Baculovirus
	Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a ...
TMPH-01849	Human parvovirus B19 (isolate AU) Non-capsid protein NS-1 (His & SUMO)	HPV B19	E. coli
	Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin o...
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GAS6 Protein, Mouse, Recombinant (His)

TMPY-04830

Species: Mouse

Expression System: HEK293

GADD45A Protein, Human, Recombinant (His & GST)

TMPY-02150

Species: Human

Expression System: Baculovirus-Insect Cells

GAS6 Protein, Human, Recombinant (hFc)

TMPJ-00366

Species: Human

Expression System: Human Cells

MAD2L1 Protein, Human, Recombinant (His)

TMPY-02238

Species: Human

Expression System: E. coli

GAS7 Protein, Human, Recombinant (His)

TMPJ-00692

Species: Human

Expression System: E. coli

GADD45G Protein, Human, Recombinant

TMPY-03655

Species: Human

Expression System: E. coli

GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated

TMPJ-00365

Species: Human

Expression System: Human Cells

GADD45A Protein, Human, Recombinant (His)

TMPJ-00907

Species: Human

Expression System: E. coli

GADD45B Protein, Human, Recombinant (His)

TMPJ-00700

Species: Human

Expression System: E. coli

GADD45G Protein, Human, Recombinant (His)

TMPJ-00711

Species: Human

Expression System: E. coli

TL1A Protein, Mouse, Recombinant

TMPJ-00603

Species: Mouse

Expression System: E. coli

GALNT7 Protein, Human, Recombinant (His)

TMPY-00365

Species: Human

Expression System: HEK293

ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK)

TMPY-00981

Species: Human

Expression System: HEK293

AXL Protein, Human, Recombinant (His)

TMPY-01601

Species: Human

Expression System: HEK293

ICAM-1/CD54 Protein, Human, Recombinant (His)

TMPY-01142

Species: Human

Expression System: HEK293

ICAM-1/CD54 Protein, Rhesus, Recombinant (His)

TMPY-05017

Species: Rhesus

Expression System: HEK293

ICAM-1/CD54 Protein, Mouse, Recombinant (His)

TMPY-01349

Species: Mouse

Expression System: HEK293

ALK-2/ACVR1 Protein, Human, Recombinant (His)

TMPY-04774

Species: Human

Expression System: Baculovirus-Insect Cells

E-Selectin/CD62E Protein, Human, Recombinant (His)

TMPY-01167

Species: Human

Expression System: HEK293

CD3D Protein, Human, Recombinant (His)

TMPY-01196

Species: Human

Expression System: HEK293

MAGEA4 Protein, Human, Recombinant (His)

TMPH-01658

Species: Human

Expression System: HEK293

TMPRSS11A Protein, Human, Recombinant (His)

TMPH-02234

Species: Human

Expression System: E. coli

MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)

TMPH-01659

Species: Human

Expression System: E. coli

CDTA Protein, E. coli, Recombinant (His)

TMPH-00604

Species: E. coli

Expression System: E. coli

CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)

TMPH-00605

Species: E. coli

Expression System: E. coli

SRP72 Protein, Human, Recombinant (GST)

TMPH-02111

Species: Human

Expression System: E. coli

ZBTB17 Protein, Human, Recombinant (His)

TMPJ-01097

Species: Human

Expression System: E. coli

Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)

TMPH-03415

Species: RVFV

Expression System: E. coli

HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc)

TMPH-01520

Species: HIV-1

Expression System: E. coli

HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)

TMPH-01519

Species: HIV-1

Expression System: E. coli

GAS6 Protein, Cynomolgus, Recombinant (His)

TMPK-00517

Species: Cynomolgus

Expression System: HEK293

AMIGO2 Protein, Cynomolgus, Recombinant (His)

TMPK-00660

Species: Cynomolgus

Expression System: HEK293

AMIGO2 Protein, Mouse, Recombinant (His)

TMPK-01072

Species: Mouse

Expression System: HEK293

ICAM-1/CD54 Protein, Cynomolgus, Recombinant (His)

TMPK-00497

Species: Cynomolgus

Expression System: HEK293

ICAM-1/CD54 Protein, Canine, Recombinant (His)

TMPK-00872

Species: Canine

Expression System: HEK293

PIG3 Protein, Human, Recombinant (His)

TMPY-01561

Species: Human

Expression System: E. coli

PRAP1 Protein, Human, Recombinant (mFc)

TMPY-03048

Species: Human

Expression System: HEK293

PRAP1 Protein, Human, Recombinant (His)

TMPY-03076

Species: Human

Expression System: HEK293

PRAME Protein, Human, Recombinant (E. coli, His)

TMPH-01650

Species: Human

Expression System: E. coli

PRAME Protein, Human, Recombinant (His)

TMPH-01651

Species: Human

Expression System: Yeast

Cornulin Protein, Human, Recombinant (His)

TMPJ-01372

Species: Human

Expression System: E. coli

TXNIP Protein, Human, Recombinant (B2M & His)

TMPH-02200

Species: Human

Expression System: in vitro E. coli expression system

TXNIP Protein, Mouse, Recombinant (His)

TMPH-02929

Species: Mouse

Expression System: Yeast

BLK Protein, Human, Recombinant (His)

TMPJ-00307

Species: Human

Expression System: E. coli

Human adenovirus C serotype 5 Early E1A protein (His & SUMO)

TMPH-00900

Species: HAdV-5

Expression System: E. coli

NSMCE3 Protein, Human, Recombinant (His)

TMPH-01781

Species: Human

Expression System: E. coli

Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (E. coli, His)

TMPH-02454

Species: MeV

Expression System: E. coli

HEPACAM2 Protein, Rat, Recombinant (His)

TMPY-03068

Species: Rat

Expression System: HEK293

Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (His)

TMPH-02453

Species: MeV

Expression System: Baculovirus

Human parvovirus B19 (isolate AU) Non-capsid protein NS-1 (His & SUMO)

TMPH-01849

Species: HPV B19

Expression System: E. coli

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カタログ番号	製品名
L8100	Cell Cycle Compound Library	695 compounds
	A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);
L2140	Cancer Cell Differentiation Compound Library	413 compounds
	A unique collection of 413 cancer cell differentiation inducing compounds for high throughput and high content screening;

ライブラリー

Cell Cycle Compound Library

L8100

Compounds: 695

Cancer Cell Differentiation Compound Library

L2140

Compounds: 413