Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively.
説明 | Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively. |
ターゲット&IC50 | CPT1 (rat heart):77 μM (IC50), CPT1 (rat liver):148 μM (IC50) |
In vitro | Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells[2]. |
In vivo | The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. |
分子量 | 393.56 |
分子式 | C23H39NO4 |
CAS No. | 6724-53-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (69.87 mM)
You can also refer to dose conversion for different animals. 詳細
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Perhexiline maleate 6724-53-4 Metabolism Others Mitochondrial Metabolism inhibit Perhexiline Perhexiline Maleate Inhibitor inhibitor