Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 13,500 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 73,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 15,500 |
説明 | PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2]. |
ターゲット&IC50 | m-calpain:5.33 μM, μ calpain:260 nM |
In vivo | PD151746 reduces the cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells. It also effectively mitigates the hydrolysis of SLLVY-AMC induced by marine toxins in SY5Y cells. |
分子量 | 237.25 |
分子式 | C11H8FNO2S |
CAS No. | 179461-52-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 44 mg/mL (185.5 mM)
Ethanol: 44 mg/mL (185.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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PD 151746 179461-52-0 Proteases/Proteasome Ubiquitination Cysteine Protease Proteasome PD-151746 PD151746 Inhibitor inhibitor inhibit