Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
説明 | Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. |
ターゲット&IC50 | Metallob-lactamase enzyme CphA (bacterial):178 μM (IC50), Renal dehydropeptidase I:0.1 μM (IC50) |
別名 | MK0791 |
分子量 | 358.45 |
分子式 | C16H26N2O5S |
CAS No. | 82009-34-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (125.54 mM)
You can also refer to dose conversion for different animals. 詳細
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Cilastatin 82009-34-5 Microbiology/Virology Proteases/Proteasome Ubiquitination Antibacterial Antibiotic Proteasome CphA metallob-lactamase MK-0791 dehydropeptidase Bacterial MK 0791 zinc antibacterial Renal adjunct Inhibitor peptidase MK0791 inhibit inhibitor