keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).
説明 | Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM). |
ターゲット&IC50 | Pim1:0.34 μM, Pim2:3.5 μM |
In vitro | Quercetagetin inhibits PIM2, PKA, and RSK2 (IC50s: 3.45, 21.2, and 2.82 μM). Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM [2]. |
In vivo | Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively [3]. |
細胞研究 | Cell Line: RWPE2 prostate cancer cells. Concentration: 0.1, 1, 10, and 100 μM. Incubation Time: 72 hours [2] |
動物実験 | Animal Model: SKH-1 hairless mice model. Dosage: 4 or 20 nmol. Administration: Topical application; 28 weeks [3] |
植物由来 |
別名 | 6-Hydroxyquercetin |
分子量 | 318.24 |
分子式 | C15H10O8 |
CAS No. | 90-18-6 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (392.79 mM)
You can also refer to dose conversion for different animals. 詳細
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Quercetagetin 90-18-6 Chromatin/Epigenetic JAK/STAT signaling Pim Pim kinases 6-Hydroxyquercetin inhibit Inhibitor inhibitor