Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 11,500 | |||
10 mg | 在庫あり | ¥ 15,000 | |||
25 mg | 在庫あり | ¥ 28,000 | |||
50 mg | 在庫あり | ¥ 50,500 | |||
100 mg | 在庫あり | ¥ 82,500 | |||
500 mg | 在庫あり | ¥ 198,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM). |
ターゲット&IC50 | DPP4:26 nM |
In vitro | In vitro, saxagliptin inhibits FBS-, insulin- and IGF1-induced ERK phosphorylation and cell proliferation, in both MSC and MC3T3E1 preosteoblasts. In the absence of growth factors, saxagliptin has no effect on ERK activation or cell proliferation. In both MSC and MC3T3E1 cells, saxagliptin in the presence of FBS inhibits Runx2 and osteocalcin expression, type-1 collagen production and mineralization, while increasing PPAR-gamma expression[4]. |
In vivo | Saxagliptin exerts direct beneficial effects on the arterial wall in an animal model of type 2 diabetes by increasing NO availability and improving antioxidant status. Saxagliptin reverses vascular hypertrophic remodeling and ameliorates NO availability in small arteries from db/db mice through the abrogation of NAD(P)H oxidase-driven eNOS uncoupling and by reducing the action of cyclooxygenase-1-derived vasoconstrictors downregulating the expression of thromboxane-prostanoid receptors[2]. DPP-4 inhibition with saxagliptin also improves pancreatic β-cell function in postprandial and fasting states, and decreases postprandial glucagon concentration[3]. |
細胞研究 | Sub-confluent cells are serum-starved overnight and then incubated with 1.5 or 15 μM saxagliptin and/or FBS (1%), insulin (5 ng/mL) or IGF1 (10-8 M) for 24 h (effects on cell proliferation) or 1 h (effects on signal transduction mechanisms). (Only for Reference) |
別名 | Onglyza hydrate, BMS-477118 hydrate |
分子量 | 333.43 |
分子式 | C18H25N3O2·H2O |
CAS No. | 945667-22-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 61 mg/mL (182.9 mM)
H2O: 1 mg/mL (3 mM)
Ethanol: 61 mg/mL (182.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Saxagliptin hydrate 945667-22-1 Proteases/Proteasome Ubiquitination DPP-4 Proteasome DPP glucagon-like c-myc BMS-477118 glucagon β-catenin BMS 477118 Saxagliptin BMS477118 insulin Onglyza hydrate proliferation Onglyza Hydrate p-AKT Inhibitor peptide-1 BMS-477118 Hydrate BMS-477118 hydrate diabetes Dipeptidyl Peptidase Saxagliptin Hydrate BMS477118 Hydrate inhibit BMS 477118 Hydrate inhibitor