Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the toll-like receptor 4 (TLR-4)-mediated formation of proinflammatory cytokines.
説明 | Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the toll-like receptor 4 (TLR-4)-mediated formation of proinflammatory cytokines. |
ターゲット&IC50 | DPP4:<10 nM |
In vitro | Alogliptin(SYR-322) is a potent inhibitor of DPP-4 and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9. Alogliptin is not an inhibitor of CYP-450 enzymes and does not block the hERG channel at concentrations up to 30 μM. [1] |
In vivo | Alogliptin(SYR-322) produces dose-dependent improvements in glucose tolerance and increases plasma insulin levels in female Wistar fatty rats. [1] Acute administration of alogliptin results in a significant decrease in plasma DPP-4 activity, and increases plasma active GLP-1. Alogliptin improves glucose tolerance at a dose of 0.3 mg/kg and higher, with a dose-dependent increase in plasma IRI, suggesting that improved glucose tolerance results from the ability of alogliptin to enhance insulin secretion. [2] |
別名 | SYR 322, Alogliptin(SYR-322)benzoate |
分子量 | 461.51 |
分子式 | C25H27N5O4 |
CAS No. | 850649-62-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 63 mg/mL (136.5 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 2 mg/mL (4.33 mM)
You can also refer to dose conversion for different animals. 詳細
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Alogliptin Benzoate 850649-62-6 Apoptosis Proteases/Proteasome Ubiquitination DPP-4 Proteasome Ferroptosis inhibit SYR-322 DPP Alogliptin diabetes Dipeptidyl Peptidase Inhibitor SYR 322 Alogliptin(SYR-322)benzoate SYR322 inhibitor