|
T39461 |
MT1
|
|
|
|
MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1). |
|
T1463 |
Ramelteon
|
TAK-375 |
Melatonin Receptor
,
MT Receptor
|
|
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
|
T3495 |
Tasimelteon
|
VEC-162,BMS-214778 |
Melatonin Receptor
,
MT Receptor
|
|
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals. |
|
T1445 |
Agomelatine
|
Thymanax,S-20098,Valdoxan |
Melatonin Receptor
,
5-HT Receptor
|
|
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. |
|
T60129 |
MT189
|
Antiproliferative agent-14 |
Microtubule Associated
|
|
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit... |
|
T11064 |
DMT1 blocker 2
|
|
Others
|
|
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo. |
|
T8841 |
IMT1
|
Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) |
Others
,
DNA/RNA Synthesis
,
Mitochondrial Metabolism
|
|
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity. |
|
T11063 |
DMT1 blocker 1
|
|
Others
|
|
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo. |
|
T8842 |
IMT1B
|
3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 |
Others
,
DNA/RNA Synthesis
|
|
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it... |
|
T71739 |
PTPMT1-IN-1
|
|
|
|
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor. |
|
T38421 |
PRMT1-IN-1
|
PRMT1-IN-1 |
|
|
PRMT1-IN-1 is a PRMT1 inhibitor. |
|
T16834 |
S26131
|
N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide |
MT Receptor
|
|
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively. |
|
T9193 |
ACH-000143
|
|
Melatonin Receptor
,
MT Receptor
|
|
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. |
|
T15795 |
Luzindole
|
N-0774 |
Melatonin Receptor
,
MT Receptor
|
|
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1... |
|
T1891 |
NSC 405020
|
|
MMP
|
|
NSC 405020 is a noncatalytic inhibitor of MT1-MMP. |
|
T10198 |
8-M-PDOT
|
8-Methoxy-2-propionamidotetralin,AH-002 |
MT Receptor
|
|
|
|
T10073 |
2-Iodomelatonin
|
|
Melatonin Receptor
|
|
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin bind... |
|
T28145 |
ND-322 HCl
|
ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl |
MMP
|
|
ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion. |
|
T34081 |
Piromelatine
|
NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor
,
5-HT Receptor
,
MT Receptor
,
Sodium Channel
,
TRP/TRPV Channel
|
|
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... |
|
T4093 |
Fabomotizole hydrochloride
|
Afobazole hydrochloride,CM346 hydrochloride |
MAO
|
|
Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro... |
|
T60523 |
Agomelatine hydrochloride
|
S-20098 hydrochloride |
MT Receptor
|
|
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, r... |
|
T14042 |
4-P-PDOT
|
4-phenyl-2- propionamidotetralin |
Melatonin Receptor
,
MT Receptor
|
|
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. |
|
T22530 |
6-Chloromelatonin
|
|
Melatonin Receptor
,
Dopamine Receptor
|
|
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]... |
|
T17095 |
TIK-301
|
PD-6735,LY-156735 |
5-HT Receptor
|
|
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an... |
|
T80217 |
BT1718
|
|
MMP
|
|
BT1718 is a bicyclic peptide conjugate that targets MT1-MMP, a protease overexpressed in various advanced solid tumors such as triple-negative breast cancer (TNBC) and non-small cell lung cancer [1] [2]. By exploiting MT... |
|
T10267 |
Agomelatine (L(+)-Tartaric acid)
|
S-20098 L(+)-Tartaric acid |
5-HT Receptor
|
|
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonis... |
|
T70035 |
Tasimelteon-d5
|
|
|
|
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ... |
|
T27430 |
GR 196429
|
GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429 |
|
|
GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice. |
|
T12689 |
Ramelteon metabolite M-II
|
|
Others
|
|
Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin. |
|
T10193 |
7-Desmethyl-agomelatine
|
|
Others
|
|
7-Desmethyl-agomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist. |
|
T10192 |
7-Desmethyl-3-hydroxyagomelatine
|
3-Hydroxy-7-desmethyl agomelatine |
5-HT Receptor
|
|
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist. |
|
T10266 |
Agomelatine-d6
|
Agomelatine D6,S-20098 D6 |
Others
|
|
Agomelatine D6 (S-20098 D6) is a deuterium-labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors. |
|
T70073 |
Fabomotizole dihydrochloride
|
|
|
|
Fabomotizole, also known as Afobazole, Obenoxazine and CM346, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant action... |
|
T78436 |
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
|
|
MMP
|
|
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for the real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1)... |
|
T71963 |
(−)-WIN 55,212-3 mesylate
|
|
|
|
(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism ... |
|
T60490 |
Melatonin receptor agonist 1
|
|
|
|
Melatonin receptor agonist 1 (compound 20c) is a potent agonist of melatonin receptor (MT) with Ki values of 108 nM for MT2 and 1140 nM for MT 1 [1]. |
|
TMIH-0486 |
Ramelteon-d5
|
|
|
|
Ramelteon-d5 is a deuterated compound of Ramelteon. Ramelteon has a CAS number of 196597-26-9. Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
|
TMIH-0485 |
Ramelteon-d3
|
|
|
|
Ramelteon-d3 is a deuterated compound of Ramelteon. Ramelteon has a CAS number of 196597-26-9. Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
|
T28645 |
S-22153
|
|
|
|
S22153 is an antagonist of melatonin receptor. |
