Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
説明 | Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease. |
ターゲット&IC50 | M3 mAChR:0.18 Nm(ki) |
In vivo | In anesthetized dogs, TD-4208, along with tiotropium and glycopyrronium, produced sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours. In anesthetized rats, inhaled TD-4208 exhibited dose-dependent 24-hour bronchoprotection against methacholine-induced bronchoconstriction. The estimated 24-hour potency (expressed as concentration of dosing solution) was 45.0 μg/ml[1]. |
別名 | TD-4208, GSK1160724 |
分子量 | 597.75 |
分子式 | C35H43N5O4 |
CAS No. | 864750-70-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (209.12 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Revefenacin 864750-70-9 Neuroscience AChR GSK 1160724 TD-4208 inhibit GSK1160724 Muscarinic acetylcholine receptor Inhibitor mAChR TD4208 TD 4208 GSK-1160724 inhibitor