Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 14,000 | |||
10 mg | 在庫あり | ¥ 22,000 | |||
25 mg | 在庫あり | ¥ 38,000 | |||
50 mg | 在庫あり | ¥ 58,000 | |||
100 mg | 在庫あり | ¥ 99,500 | |||
500 mg | 在庫あり | ¥ 225,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,500 |
説明 | Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension. |
In vitro | BAY 63-2521 (Riociguat) concentration-dependently stimulates the recombinant soluble guanylate cyclase (sGC) from 0.1 to 100 μM, resulting in a two-fold to 73-fold increase, through an NO-independent but haem-dependent mechanism. [1] Additionally, Riociguat impairs platelet function in isolated platelets, though it does not affect platelets in whole blood, nor does it directly influence the contractility and relaxation of cardiac myocytes. [2] [3] |
In vivo | In a long-term study, Riociguat (10 mg/kg/d, orally) was found to partially mitigate pulmonary arterial hypertension, right heart hypertrophy, and structural remodeling of lung vasculature in hypoxic mice and monocrotaline (MCT)-injected rats. [1] |
別名 | BAY 632521 |
分子量 | 422.42 |
分子式 | C20H19FN8O2 |
CAS No. | 625115-55-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 78 mg/mL (184.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Riociguat 625115-55-1 GPCR/G Protein Guanylate cyclase Inhibitor BAY-632521 inhibit Guanylate Cyclase BAY632521 BAY 632521 inhibitor