Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. It increases extracellular aspartate and glutamate in the frontal cortex and exhibits anticonvulsant activity (EC50: 0.16 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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2 mg | 在庫あり | ¥ 8,500 | |||
5 mg | 在庫あり | ¥ 12,500 | |||
10 mg | 在庫あり | ¥ 23,000 | |||
25 mg | 在庫あり | ¥ 51,000 | |||
50 mg | 在庫あり | ¥ 97,000 | |||
100 mg | 在庫あり | ¥ 144,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,000 |
説明 | SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. It increases extracellular aspartate and glutamate in the frontal cortex and exhibits anticonvulsant activity (EC50: 0.16 μM). |
ターゲット&IC50 | 5-HT6:8.92(pKi) |
別名 | SB 271046A |
分子量 | 488.45 |
分子式 | C20H22ClN3O3S2·HCl |
CAS No. | 209481-24-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (92.13 mM)
You can also refer to dose conversion for different animals. 詳細
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SB 271046 hydrochloride 209481-24-3 GPCR/G Protein Neuroscience 5-HT Receptor oral test Serotonin Receptor SB271046 Inhibitor inhibit 5-hydroxytryptamine Receptor SB-271046 SB 271046 Hydrochloride SB 271046 channels SB 271046A anticonvulsant SB271046 Hydrochloride SB-271046 Hydrochloride selective MEST inhibitor