Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH79797 dihydrochloride is a selective antagonist of nonpeptide protease activated receptor 1 (PAR1).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 12,500 | |||
5 mg | 在庫あり | ¥ 29,500 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 91,500 | |||
50 mg | 在庫あり | ¥ 142,000 | |||
100 mg | 在庫あり | ¥ 202,000 |
説明 | SCH79797 dihydrochloride is a selective antagonist of nonpeptide protease activated receptor 1 (PAR1). |
In vitro | SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. In NIH 3T3 cells, SCH79797 dihydrochloride inhibits serum-stimulated activation of p44/p42 mitogen-activated protein kinases (MAPK) at low concentrations and induces apoptosis at higher concentrations[1]. SCH79797 dihydrochloride inhibits high-affinity thrombin receptor-activating peptide ([3H]haTRAP) binding in a competitive manner. SCH79797 dihydrochloride inhibits α-thrombin- and haTRAP-induced aggregation of human platelets. Thrombin produces transient increases in cytosolic free Ca2+ concentration ([Ca2+]i) in hCASMC. SCH79797 dihydrochloride effectively inhibits this increase in [Ca2+]i. SCH79797 dihydrochloride completely inhibits Thrombin- and TK-stimulated [3H]thymidine incorporation [4]. |
In vivo | In male Sprague Dawley rats, SCH79797 dihydrochloride (2.5 μg/kg, 10 μg/kg, 25 μg/kg, 50 μg/kg, 100 μg/kg, and 250 μg/kg; i.v.) reduces myocardial necrosis following I/R in the intact rat heart in two rat models of myocardial ischemia/reperfusion (I/R) injury immediately before or during ischemia[3]. |
分子量 | 444.4 |
分子式 | C23H27Cl2N5 |
CAS No. | 1216720-69-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL (22.50 mM), Sonication and heating are recommended.
DMSO: 20 mg/mL (45.00 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SCH79797 dihydrochloride 1216720-69-2 Apoptosis GPCR/G Protein Others Protease-activated Receptor infarct SCH-79797 SCH-79797 dihydrochloride SCH 79797 Inhibitor inhibit Nonpeptide SCH79797 SCH79797 Dihydrochloride thrombin wortmannin antiproliferative platelets Protease Activated Receptor (PAR) SCH 79797 Dihydrochloride pro-apoptotic thrombosis SCH-79797 Dihydrochloride Thrombin receptors PAR1 cardioprotection inhibitor