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T15052 |
Dapansutrile
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NOD-like Receptor (NLR)
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NOD
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Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity. |
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T2423 |
P7C3-A20
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Others
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P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity. |
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T12870 |
SCH79797 dihydrochloride
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Apoptosis
,
Others
,
Protease-activated Receptor
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SCH79797 dihydrochloride is a selective antagonist of nonpeptide protease activated receptor 1 (PAR1). |
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T19659 |
Annaosanchun
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YC6,YC-6,YC 6 |
Others
,
AMPK
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Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS). |
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T0368 |
Cinepazide maleate
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MD-67350,Vasodistal,Brendil |
Calcium Channel
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Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator. |
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T3230 |
NLRP3-IN-2
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5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I |
NOD-like Receptor (NLR)
,
NOD
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NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i... |
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T70540 |
Pinokalant
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LOE-908 |
SARS-CoV
,
TRP/TRPV Channel
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Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem... |
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T35689 |
MTP 131 acetate
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Others
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MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T11806 |
L-NIO dihydrochloride
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NOS
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L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM... |
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T81037 |
Tat-HA-NR2B9c
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Tat-HA-NR2B9, comprising an HIV-1 Tat transduction domain fragment, an influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c), has demonstrated efficacy in reducing infarct size... |
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T37671 |
CAY10608
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CAY10608 |
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N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that pot... |
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T70883 |
Moexipril-d5
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Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to ... |
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T75870 |
PR-39 TFA
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PR-39 TFA, a natural peptide rich in proline and arginine with antibacterial properties, acts as a noncompetitive, reversible, and allosteric inhibitor of the proteasome. It specifically attaches to the α7 subunit of the... |
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T73453 |
MRS4719
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MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can dec... |
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T21989 |
SSR 69071
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SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase. SSR69071 displays a higher affinity for human elastase (Ki =0.0168 nM) than for rat (Ki =3 nM), mouse (Ki =1.8 nM), and rabbit (Ki = 58... |
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T83695 |
MOG Peptide (human, bovine) acetate
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Myelin Oligodendrocyte Glycoprotein Peptide |
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Myelin oligodendrocyte glycoprotein (MOG) peptide, a truncated form of MOG located on the extracellular myelin sheath surface, interacts with antigen serotype HLA-DR2 to mitigate effects of ischemic stroke induced by mid... |
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T83730 |
Tat-M2NX TFA
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Tat-M2NX, a peptide antagonist of transient receptor potential melastatin 2 (TRPM2), blocks hydrogen peroxide-induced calcium influx in HEK293 cells expressing human TRPM2 at concentrations between 25 to 100 µM. In male ... |
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T71402 |
Nicorandil-d4
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Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir... |
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T83777 |
LAU-0901
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LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO)-induced ... |
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T35463 |
(±)14(15)-EET
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(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET |
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(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) i... |
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T83729 |
Tat-CIRP TFA
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Tat-Cold-inducible RNA Binding Protein |
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Tat-CIRP, a peptide inhibitor, impedes the protein-protein interaction between myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96), and cold-inducible RNA binding protein (CIRP) by binding to MD-... |
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T83727 |
Tat-NTS Peptide TFA
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Tat-Nuclear Translocation Signal Peptide |
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Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran... |
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T83682 |
Tat-Gap 19 TFA
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Tat-Gap 19, a peptide inhibitor of connexin43 (Cx43) hemichannels, is derived from the HIV-1 Tat protein transduction domain fused with a nine-amino acid sequence from Cx43 residues 128-136. This compound, at a concentra... |
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T83769 |
TC 14012 hydrochloride
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H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 |
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TC 14012, a peptidomimetic compound, acts as both an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 2.9 nM) and as an agonist for CXCR7, effectively recruiting β-arrestin in HEK293T cells that expres... |
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T83731 |
Tat-CBD3 TFA
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Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA ... |
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T83825 |
Trofinetide acetate
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NNZ-2566 |
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Trofinetide, derived from the neuroprotective tripeptide Gly-Pro-Glu (an N-terminal sequence of insulin-like growth factor-1, IGF-1), shows promise in various neuroprotective models. At a concentration of 10 nM, it mitig... |
