|
T11696 |
Ivachtin
|
Caspase-3 Inhibitor VII |
Caspase
|
|
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases. |
|
T11857 |
LIT-001
|
|
Oxytocin Receptor
|
|
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM. |
|
T16850 |
SB-265610
|
GSK-CXCR2 |
CXCR
|
|
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and... |
|
T6288 |
Mozavaptan
|
OPC31260l,OPC-31260 |
Vasopressin Receptor
|
|
Mozavaptan (OPC-31260) is a competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively. |
|
T12870 |
SCH79797 dihydrochloride
|
|
Apoptosis
,
Others
,
Protease-activated Receptor
|
|
SCH79797 dihydrochloride is a selective antagonist of nonpeptide protease activated receptor 1 (PAR1). |
|
T3178 |
BIBS 39
|
|
RAAS
|
|
BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. |
|
T21790 |
BMS 182874 hydrochloride
|
|
Endothelin Receptor
|
|
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. |
|
T16034 |
Meclinertant
|
SR 48692 |
Others
|
|
Meclinertant is an effective, selective, nonpeptide, and orally active neurotensin receptor 1 (NTS1) antagonist. Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization (pA2 : 8.13), in... |
|
T3347 |
PF3274167
|
PF 3274167,Cligosiban,PF-3274167 |
OX Receptor
|
|
PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. |
|
T27762 |
L-162,313
|
L-162313,L 162,313,L162,313 |
RAAS
|
|
L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP. |
|
T1520 |
Aliskiren hemifumarate
|
CGP 60536,SPP 100,CGP60536B |
RAAS
,
Autophagy
|
|
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity. |
|
T6281 |
TW-37
|
TW 37 |
BCL
|
|
TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM). |
|
T26594 |
Allisartan Isoproxil
|
|
RAAS
|
|
Allisartan Isoproxil is a nonpeptide antagonist of angiotensin II receptor and can be used in studies about hypertension and heart diseases. |
|
T9692 |
Paltusotine
|
|
Somatostatin
|
|
Paltusotine is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability. Paltusotine maintains GH and IGF-1 levels in acromegaly patients |
|
T25615 |
Lanepitant
|
LY303870,LY-303870,LY 303870 |
Others
|
|
Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine. |
|
TQ0057 |
AVE 0991
|
|
Others
|
|
AVE 0991, a nonpeptide analog of angiotensin-(1-7) [Ang-(1-7)], is an orally active Mas agonist with inhibitory effects on [125I]-Ang-(1-7) binding to bovine aortic endothelial cell membranes, and inhibits astrocyte-medi... |
|
T36008 |
Nebentan potassium
|
YM598 |
Endothelin Receptor
|
|
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurolog... |
|
T8691 |
PD 168368
|
PD168368 |
Bombesin Receptor
|
|
PD 168368 is a novel, potent, competitive and selective nonpeptide neuromodulin B receptor (NMB-R) antagonist with inhibitory effects on the gastrin-releasing peptide receptor (GRPR).PD 168368 is a potent mixed agonist o... |
|
T11174 |
(R)-Elagolix
|
NBI-56418 |
GNRH Receptor
|
|
(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a do... |
|
T39229 |
YNT-185
|
|
OX Receptor
|
|
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of ... |
|
T6825 |
Eltrombopag Olamine
|
Promacta Olamine,Revolade,Eltrombopag diethanolamine salt,SB497115,SB-497115GR |
Thrombin
|
|
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrom... |
|
T2531L |
Eprosartan
|
KF-108566J free base,Teveten |
RAAS
|
|
Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ... |
|
T29234 |
ZM 253270
|
ZM253270,ZM-253270 |
|
|
ZM 253270 is an nonpeptide neurokinin A antagonist. |
|
T27940 |
LY301875
|
LY 301875,LY-301875 |
|
|
LY301875 is an antagonist of nonpeptide angiotensin receptor. |
|
T70137 |
CAM 4515
|
|
|
|
CAM 4515 is a nonpeptide tachykinin NK1 receptor antagonist. |
|
T25895 |
NVP-SAA164
|
SAA 164,SAA164,SAA-164,NVP SAA164 |
|
|
NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent. |
|
T70136 |
CAM 4750
|
|
|
|
CAM 4750 is a nonpeptide tachykinin NK1 receptor antagonist. |
|
T16935 |
SR 146131
|
|
Others
|
|
|
|
T25608 |
Lamifiban trifluoroacetate
|
Lamifiban trifluoroacetate salt |
|
|
Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa). |
|
T29177 |
YM 218
|
YM218,YM-218 |
|
|
YM 218 is a novel, potent, selective antagonist of nonpeptide vasopressin V1A receptor. |
|
T70295 |
MDL-105212A HCl
|
|
|
|
MDL-105212A HCl is a nonpeptide NK-1 and NK-2 receptor antagonist. |
|
T12331 |
OT-R antagonist 2
|
Oxytocin receptor antagonist 2 |
Others
|
|
OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R . |
|
T28322 |
PD 123177
|
PD-123177,PD123177,Exp-655,Exp655,Exp 655 |
|
|
PD 123177 is an inhibitor of Nonpeptide angiotensin AII-2. |
|
T70272 |
L-162782
|
|
|
|
L-162782 is a nonpeptide agonist of angiotensin AT1 receptor. |
|
T28813 |
SM19712 sodium
|
SM 19712,SM19712,SM-19712 |
|
|
SM19712 sodium is an inhibitor of nonpeptide endothelin converting enzyme. |
|
T69097 |
ARD-353
|
|
|
|
ARD-353 is a nonpeptide delta receptor agonist with cardioprotective effects. |
|
T28814 |
SM19712 free acid
|
SM 19712,SM-19712,SM19712 |
|
|
SM19712 free acid is an inhibitor of nonpeptide endothelin converting enzyme. |
|
T68486 |
Fasitibant
|
|
|
|
Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist. |
|
T16085 |
MK-0429
|
L-000845704 |
Others
|
|
MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM). |
|
T25607 |
Lamifiban
|
Ro-44-9883/000,Ro 44-9883/000,Ro44-9883/000 |
|
|
Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass. |
|
T70658 |
Ici D8731
|
|
|
|
Ici D8731 is a nonpeptide angiotensin II antagonist with potential as a treatment for hypertension and heart failure. |
|
T70225 |
L-159884
|
|
|
|
L-159884 is a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging |
|
T16895 |
SL910102
|
|
Others
|
|
SL910102 is a nonpeptide angiotensin antagonist of the AT1 receptor. |
|
T11862 |
LMD-009
|
|
Others
|
|
LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. LMD-009 is a selective CCR8 nonpeptide agonist. |
|
T61079 |
RXFP3 agonist 1
|
|
|
|
RXFP3 agonist 1 is a nonpeptide RXFP3 agonist ( EC 50 =6937 nM) [1]. |
|
T15101 |
Devazepide
|
L-364,718,MK-329 |
Others
|
|
Devazepide is a competitive and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor (IC50s: 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respective... |
|
T26802 |
BIBS-222
|
BIBS 222 |
|
|
BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat. |
|
T70410 |
Cam 2445
|
|
|
|
Cam 2445 is a nonpeptide, alpha-methyltryptophan derivative; an NK1 neurokinin receptor antagonist that is a potentially useful treatment for arthritis, asthma, migraine, anxiety, psychosis, and emesis. |
|
T12331L |
OT-R antagonist 1
|
Oxytocin receptor antagonist 1 |
Others
|
|
OT-R antagonist 1 inhibits oxytocin-evoked intracellular Ca2+ mobilization (IC50 = 8 nM). OT-R antagonist 1 is a new effective and selective nonpeptide low molecular weight OT-R antagonist. |
|
T16358 |
NTRC-824
|
|
Others
|
|
NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM). |
