Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
説明 | SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo. |
ターゲット&IC50 | CARM1:50 nM |
分子量 | 348.87 |
分子式 | C19H24N2O2·HCl |
CAS No. | 1821908-49-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (157.65 mM)
You can also refer to dose conversion for different animals. 詳細
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SGC2085 HCl 1821908-49-9 Chromatin/Epigenetic Histone Methyltransferase SGC-2085 HCl Inhibitor inhibitor inhibit