Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1
説明 | SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1 |
In vitro | SRS11-92 inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM).?SRS11-92 (2 M) inhibits iron-induced cell death in isolated mouse kidney proximal tubules, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM. |
In vivo | SRS11-92 increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington s disease in a concentration-dependent manner.?SRS11-92 (3 M) increases production of reactive oxygen species (ROS) in L. major promastigotes in a time-dependent manner.?It is selectively toxic to L. major promastigotes (LD50 = 3.34 M) over U2OS human osteoblasts, RAW 264.7 macrophages, and intraperitoneal macrophages when used at a concentration of 80 M. |
別名 | AA9 |
分子量 | 352.47 |
分子式 | C22H28N2O2 |
CAS No. | 1467047-25-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (28.37 mM)
You can also refer to dose conversion for different animals. 詳細
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SRS11-92 1467047-25-1 Apoptosis Ferroptosis HT-1080 FRDA Friedreich Inhibitor cell death AA-9 AA 9 ataxia AA9 SRS-11-92 SRS1192 inhibit SRS11 92 inhibitor