|
T9989 |
AChE-IN-27
|
|
Others
|
|
AChE-IN-27 is a small molecule used for high-throughput assays. |
|
T5175 |
Azd1390
|
|
ATM/ATR
|
|
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes. |
|
T3338 |
Ceralasertib
|
AZD6738 |
ATM/ATR
|
|
Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. |
|
T4443 |
AZ32
|
|
ATM/ATR
|
|
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. |
|
T1958 |
AZ20
|
|
ATM/ATR
,
mTOR
|
|
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR. |
|
T6770 |
AZD0156
|
|
Apoptosis
,
ATM/ATR
|
|
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing. |
|
T3032 |
VE-821
|
ATR Inhibitor IV |
ATM/ATR
|
|
VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays). |
|
T1821 |
CGK733
|
CGK 733 |
ATM/ATR
|
|
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. |
|
T6612 |
NU6027
|
|
ATM/ATR
,
DNA-PK
,
CDK
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. |
|
T6261 |
CP-466722
|
CP 466722,CP466722 |
ATM/ATR
|
|
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells. |
|
T2084 |
ETP-46464
|
|
ATM/ATR
,
DNA-PK
,
PI3K
,
mTOR
|
|
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM). |
|
T9522 |
Rimtuzalcap
|
CAD-1883 |
Potassium Channel
|
|
Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spin... |
|
T8922 |
SRS11-92
|
AA9 |
Ferroptosis
|
|
SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1 |
|
T7318 |
Elimusertib
|
BAY-1895344 |
ATM/ATR
|
|
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... |
|
T2685 |
KU-55933
|
ATM Kinase Inhibitor |
ATM/ATR
,
DNA-PK
,
PI3K
,
mTOR
,
Autophagy
|
|
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor. |
|
T7122 |
AZD-7648
|
|
DNA-PK
|
|
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity. |
|
T19663 |
Triheptanoin
|
UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011 |
Others
|
|
Triheptanoin (IND 106011) is a fatty acid metabolic modulator. It potentially for the treatment of fatty acid oxidation disorders and GLUT1. |
|
T10406 |
Tuvusertib
|
M1774,ATR inhibitor 1 |
Apoptosis
,
ATM/ATR
,
Others
,
Chk
|
|
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks... |
|
T16345 |
NS13001
|
N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine,N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine |
Potassium Channel
|
|
NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium ch... |
|
T20826 |
Dioxabenzofos
|
Salithion |
|
|
Dioxabenzofos, a pesticide, could cause reversible ataxia in mice, chicken, and sheep. |
|
T40077 |
ATR-IN-9
|
|
|
|
ATR-IN-9 is a highly effective inhibitor of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). With an IC50 value as low as 10 nM, ATR-IN-9 demonstrates exceptional potency. |
|
T76419 |
Protein Kinase C γ Peptide
|
|
|
|
Protein Kinase C (gamma) Peptide, a fragment of Protein Kinase Cγ, plays a role in dominant ataxia by inhibiting the nuclear import of aprataxin, which is associated with recessive ataxia [1]. |
|
T69017 |
Ibotenic acid hydrate
|
|
|
|
Ibotenic acid hydrate is a neurotoxic isoxazole (similar to Kainic acid and Muscimol) found in Amanita mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitat... |
|
T39523 |
Antitumor agent-28
|
|
|
|
Antitumor agent-28 is a compound that specifically targets and inhibits the activity of the ataxia telangiectasia mutated (ATM) kinase. By doing so, it effectively impedes the progression of ATM-mediated diseases and dem... |
|
T83753 |
RAD17-derived Peptide TFA
|
|
|
|
RAD17-derived peptide, a substrate for the ataxia-telangiectasia and RAD3-related protein/kinase (ATR), facilitates the identification of ATR inhibitors. |
|
T40212 |
ATR-IN-4
|
|
|
|
ATR-IN-4, a potent inhibitor of ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase), restricts the growth of DU145 prostate cancer cells and NCI-H460 lung cancer cells, with IC 50 values of 130.9 nM and 41.3... |
|
T78711 |
A011
|
|
ATM/ATR
|
|
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumo... |
|
T26981 |
Ceralasertib formate
|
Ceralasertib,AZD-6738,AZD 6738,AZD6738 |
|
|
Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine prot... |
|
T81638 |
NSC363998 free base
|
|
|
|
NSC363998 (free base), an orally active compound, suppresses rCGG90-induced neurotoxicity and is utilized in researching neurodegenerative disorders, including Fragile X associated tremor/ataxia syndrome (FXTAS) [1]. |
|
T62965 |
TDP1 Inhibitor-2
|
|
|
|
TDP1 Inhibitor-2 is a potent inhibitor of TDP1 (tyrosyl-DNA phosphodiesterase 1) (IC50: 99 nM) and inhibits SCAN1 (spinal cerebellar ataxia syndrome with axonal neuropathy) (IC50: 3.5 μM). |
|
T83950 |
ARN 11391
|
|
|
|
ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion signaling by directly targeting ITPR1. Furthermore, ARN 1139... |
|
T36003 |
1(R)-(Trifluoromethyl)oleyl alcohol
|
|
|
|
1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder c... |
|
T62563 |
ATR-IN-12
|
|
|
|
ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia capillaris and Rad3-related (ATR) kinase (IC50: 0.007 μM). ATR-IN-12 is a promising lead compound for subsequent drug discovery studies on ATR kinases. |
|
T62651 |
ATR-IN-11
|
|
|
|
ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia capillaris and Rad3-related (ATR) kinases. ATR-IN-11 is a promising lead compound for the discovery of subsequent drugs targeting the ATR kinase, a key regulator... |
|
T35942 |
AZ 5704
|
|
|
|
Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Pot... |
|
T65396 |
Piperazine 2HCl
|
|
|
|
Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspecte... |
