Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.
説明 | STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM. |
ターゲット&IC50 | GLUT1:1 μM. |
In vitro | STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. [1] In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. [2] STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. [3] |
In vivo | In mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth. [1] |
分子量 | 423.53 |
分子式 | C23H25N3O3S |
CAS No. | 724741-75-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 25 mg/mL (59.03 mM)
DMSO: 42.4 mg/mL(100 mM)
You can also refer to dose conversion for different animals. 詳細
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STF-31 724741-75-7 Autophagy Metabolism transporter VHL inhibitor RCC4/VHL STF31 GLUT Glucose transporter GLUT1 inhibit glucose RCC4 STF 31 Inhibitor