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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T83649 | VHL 15a | ||
T13958 | VHL Ligand 8 | Others | |
VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive p... | |||
T7752 | (S,R,S)-AHPC-Me | VHL ligand 2,E3 ligase Ligand 1A | Ligand for E3 Ligase |
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a... | |||
T35479 | CRBN-6-5-5-VHL | ||
Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. ... | |||
T4207 | (S,R,S)-AHPC hydrochloride | VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). | |||
T8412 | (S,R,S)-AHPC | VH032-NH2,MDK7526,VHL ligand 1 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. | |||
T17927 | (S,R,S)-AHPC TFA | VH032-NH2 TFA,VHL ligand 1 TFA | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea... | |||
T13671 | (S,R,S)-AHPC-Me hydrochloride | VHL ligand 2 hydrochloride,E3 ligase Ligand 1 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell... | |||
T17922 | (S,R,S)-AHPC-PEG3-NH2 hydrochloride | VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl | Others , E3 Ligase Ligand-Linker Conjugate |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC-based VHL ligand and 3-unit PEG linker. | |||
T18873 | VHL Ligand-Linker Conjugates 17 | Others | |
VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, ... | |||
T17877 | VH032-cyclopropane-F | VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101 | Others , Ligand for E3 Ligase |
VH032-cyclopropane-F (Phenolic VH101) is a VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein by a linker to form PROTACs. PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4. | |||
T17908 | VHL Ligand-Linker Conjugates 15 | E3 Ligase Ligand-Linker Conjugates 56 | Others |
VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1]. | |||
T82928 | Azido-PEG2-VHL | PROTACs | |
Azido-PEG2-VHL is a multikinase degrader utilized in PROTACs (PROteolysis TArgeting Chimeras) synthesis [1]. | |||
T17921 | (S,R,S)-AHPC-PEG4-N3 | VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4 | Others , PROTAC Linker |
(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both c... | |||
T17924 | (S,R,S)-AHPC-PEG2-NH2 hydrochloride | VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6 | Others , E3 Ligase Ligand-Linker Conjugate |
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-NH2 hydrochloride incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit... | |||
T17909 | (S,R,S)-AHPC-PEG3-N3 | VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12 | Others , E3 Ligase Ligand-Linker Conjugate , Ligand for E3 Ligase |
(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC tec... | |||
T79720 | VHL-IN-1 | HIF/HIF Prolyl-Hydroxylase | |
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for appli... | |||
T18640 | (S,R,S)-AHPC-C4-NH2 hydrochloride | VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker. | |||
T17920 | (S,R,S)-AHPC-PEG1-N3 | VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC tec... | |||
T15190L | (S,R,S)-AHPC-PEG4-NH2 | VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-unit PEG linker. | |||
T18600 | VH032 thiol | VHL ligand 6 | Others |
VH032 thiol (VHL ligand 6) is a VHL ligand that interacts with pan-BET inhibitor JQ1 through a linker to create a PROTAC[1] compound. | |||
T17925 | (S,R,S)-AHPC-PEG2-NH2 | VH032-PEG2-NH2,VHL Ligand-Linker Conjugates 3,E3 ligase Ligand-Linker Conjugates 6 Free Base | Others , E3 Ligase Ligand-Linker Conjugate |
(S,R,S)-AHPC-PEG2-NH2 (VHL Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-NH2 incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis ... | |||
T2363 | STF-31 | transporter , Autophagy | |
STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM. | |||
T13876 | (S,R,S)-AHPC-propargyl | VHL ligand 7,VH032-propargyl | Others |
(S,R,S)-AHPC-propargyl is a VHL ligand which is used in "click reaction" for PROTACs. | |||
T18602 | VH032-thiol-C6-NH2 | VHL Ligand-Linker Conjugates 14,E3 ligase Ligand-Linker Conjugates 29 | Others |
VH032-thiol-C6-NH2, also known as VHL Ligand-Linker Conjugates 14, is a synthesized compound that functions as an E3 ligase ligand-linker conjugate. This compound combines the VH032 based VHL ligand with a linker commonl... | |||
T6683 | STF-62247 | STF 62247 | Estrogen/progestogen Receptor , Autophagy |
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. | |||
T17911 | (S,R,S)-AHPC-C6-PEG3-C4-Cl | VH032-C6-PEG3-C4-Cl,VHL Ligand-Linker Conjugates 12,E3 ligase Ligand-Linker Conjugates 8 | Others |
(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in ce... | |||
T17912 | (S,R,S)-AHPC-(C3-PEG)2-C6-Cl | VHL Ligand-Linker Conjugates 11,E3 ligase Ligand-Linker Conjugates 11 | Others |
(S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is capable of inducing the degradation of GFP-Ha... | |||
T18872 | (S,R,S)-AHPC-PEG5-COOH | VH032-PEG5-COOH,E3 Ligase Ligand-Linker Conjugates 58,VHL Ligand-Linker Conjugates 16 | Others |
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthetic E3 ligase ligand-linker conjugate developed for use in PROTAC technology. It consists of the (S,R,S)-AHPC based VHL ligand and a 5-unit PEG linker [1]. | |||
T17905 | (S,R,S)-AHPC-PEG1-OTs | VH032-PEG1-OTs,VHL Ligand-Linker Conjugates 2,E3 ligase Ligand-Linker Conjugates 51 | Others |
(S,R,S)-AHPC-PEG1-OTs is a chemically synthesized conjugate, functioning as an ligase ligand-linker for E3 ligase. It incorporates the VHL ligand derived from (S,R,S)-AHPC and a 1-unit PEG linker. This synthesized compou... | |||
T17913 | (S,R,S)-AHPC-PEG2-N3 | VHL Ligand-Linker Conjugates 6,VH032-PEG2-N3,E3 ligase Ligand-Linker Conjugates 13 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-PEG2-N3 (VHL Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate containing a (S,R,S)-AHPC based VHL ligand and 2 unit PEG linker. | |||
T17926 | (S,R,S)-AHPC-PEG6-C4-Cl | VHL Ligand-Linker Conjugates 10,E3 ligase Ligand-Linker Conjugates 9,VH032-PEG6-C4-Cl | Others |
(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-bas... | |||
T17910 | (S,R,S)-AHPC-PEG2-C4-Cl | E3 ligase Ligand-Linker Conjugates 10,VHL Ligand-Linker Conjugates 7,VH032-PEG2-C4-Cl | Others |
(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-bas... | |||
T12186 | Navitoclax-piperazine | ABT-263-piperazine | BCL , Ligands for Target Protein for PROTAC |
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL). | |||
T13671L | (S,R,S)-AHPC-Me dihydrochloride | VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) | Others |
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demon... | |||
T17923 | (S,R,S)-AHPC-PEG3-NH2 | E3 ligase Ligand-Linker Conjugates 5 Free Base,VH032-PEG3-NH2,VHL Ligand-Linker Conjugates 1 | Others |
(S,R,S)-AHPC-PEG3-NH2 is a synthetic conjugate of an E3 ligase ligand-linker, incorporating the (S,R,S)-AHPC VHL ligand and a 3-unit PEG linker, which are utilized in PROTAC technology. | |||
T15190 | (S,R,S)-AHPC-PEG4-NH2 hydrochloride | E3 ligase Ligand-Linker Conjugates 7,VH032-PEG4-NH2 hydrochloride,VHL Ligand-Linker Conjugates 4 hydrochloride | Others |
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically ... | |||
T17881 | (S,R,S)-AHPC-C10-NH2 | VH032-C10-NH2 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate, comprising the (S,R,S)-AHPC-based VHL ligand and a linker, designed for BET-targeted PROTAC applications. | |||
T18661 | (S,R,S)-AHPC-C10-NH2 dihydrochloride | VH032-C10-NH2 dihydrochloride,VH032-linker 10,VH032 amide-alkylC10-amine | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker[1]. | |||
T13722 | Homo-PROTAC pVHL30 degrader 1 | Others , Ligand for E3 Ligase | |
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC. | |||
T36275 | XStAx-VHLL | ||
Selective peptide-based β-catenin Degrader. Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively ... | |||
TQ0121 | VH-298 | Others , HIF , Ligand for E3 Ligase | |
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P... | |||
T40028 | (S,R,S)-AHPC | Ligand for E3 Ligase | |
(S,R,S)-AHPC is a VHL ligand that used in the recruitment of the VHL protein. | |||
T29106 | VH032 | VH-032,VH 032 | Ligand for E3 Ligase |
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a l... | |||
T13877 | (S,S,S)-AHPC hydrochloride | (S,S,S)-VH032-NH2 hydrochloride | Ligand for E3 Ligase |
(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the recruitment of the VHL pro... | |||
T18669L | (S,R,S)-AHPC-Me-C10-NH2 hydrochloride | Ligand for E3 Ligase | |
(S,R,S)-AHPC-Me-C10-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating a VHL ligand and a linker. | |||
T5334 | VL285 | Others , Ligand for E3 Ligase | |
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins. | |||
T18787 | TD-165 | Others , Ligand for E3 Ligase | |
TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1]. | |||
T18675 | (S,R,S)-AHPC-PEG2-NH2 dihydrochloride | VH032 amide-PEG2-amine,VH032-PEG2-NH2 dihydrochloride,VH032-linker 12 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker[1]. | |||
T10359 | AR antagonist 1 | Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC | |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-06026 | VHL Protein, Human, Recombinant (His & Avi) | Human | E. coli |
VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2. | |||
TMPJ-01138 | UBE2S Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activat... | |||
TMPY-03398 | FHIT Protein, Human, Recombinant (His) | Human | E. coli |
Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine tria... | |||
TMPH-01288 | Elongin-B Protein, Human, Recombinant (GST) | Human | E. coli |
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its... | |||
TMPH-01512 | HIF1AN Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coa... |