Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.
説明 | Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression. |
ターゲット&IC50 | 5-HT:13 nM(Ki) |
In vitro | Sertraline HCl significantly enhances locomotor activity in mice during the antidepressant Porsolt forced swim test. Intraperitoneal injection of 32 μMol/kg Sertraline HCl inhibits more than 50% of 5-hydroxytryptamine uptake by rat striatal synaptosomes. Sertraline HCl reverses 5-hydroxytryptamine depletion caused by PCA, proving to be six times more effective than chlorpromazine and sixty times more effective than amitriptyline. Acute repetitive administration of Sertraline reduces the serotonin content in whole blood. Chronic administration of Sertraline HCl in rats decreases the binding of [3H] dihydroalprenolol to cortical membranes and the cyclic AMP response to norepinephrine in the limbic forebrain adenylate cyclase. |
In vivo | Sertraline is more effective than fluvoxamine, zimelidine, norzimelidine, fluoxetine, or clomipramine in preferentially inhibiting the uptake of 5-HT (serotonin), with comparatively weaker inhibition of NE (norepinephrine) absorption. However, sertraline exhibits lower selectivity than these agents in blocking the uptake of 5-HT relative to DA (dopamine). |
別名 | Sertraline HCl, CP-51974-1 HCl |
分子量 | 342.691 |
分子式 | C17H18Cl3N |
CAS No. | 79559-97-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 34.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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