Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 60,500 | |||
10 mg | 在庫あり | ¥ 90,500 | |||
25 mg | 在庫あり | ¥ 151,000 | |||
50 mg | 在庫あり | ¥ 215,000 | |||
100 mg | 在庫あり | ¥ 291,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 59,000 |
説明 | T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM). |
ターゲット&IC50 | LSD1:2.1 nM |
In vitro | T-3775440, a novel irreversible LSD1 inhibitor. Cell growth analysis of leukemia cell lines revealed that acute erythroid leukemia (AEL) and acute megakaryoblastic leukemia cells (AMKL) were highly sensitive to this compound. T-3775440 treatment enforced transdifferentiation of erythroid/megakaryocytic lineages into granulomonocytic-like lineage cells. Mechanistically, T-3775440 disrupted the interaction between LSD1 and growth factor-independent 1B (GFI1B), a transcription factor critical for the differentiation processes of erythroid and megakaryocytic lineage cells. Knockdown of LSD1 and GFI1B recapitulated T-3775440-induced transdifferentiation and cell growth suppression, highlighting the significance of LSD1-GFI1B axis inhibition with regard to the anti-AML effects of T-3775440[1]. |
In vivo | T-3775440 exhibited significant antitumor efficacy in AEL and AMKL xenograft models[1]. |
分子量 | 346.85 |
分子式 | C18H23ClN4O |
CAS No. | 1422535-52-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30.18 mg/mL (87.01 mM)
You can also refer to dose conversion for different animals. 詳細
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