Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.
説明 | ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM. |
ターゲット&IC50 | LSD1/KDM1A:20 nM |
In vitro | In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells. [1] |
In vivo | In rodent MV(4;11) xenografts, ORY-1001 (<0.020 mg/kg, p.o.) leads to significantly reduced tumor growth. [1] |
別名 | RG-6016, ORY-1001 (RG-6016) 2HCl, ORY-1001, ORY 1001 |
分子量 | 303.27 |
分子式 | C15H22N2·2HCl |
CAS No. | 1431326-61-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (16.48 mM)
Ethanol: 1 mg/mL(3.3 mM)
H2O: 56 mg/mL (184.7 mM)
You can also refer to dose conversion for different animals. 詳細
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ORY1001 1431326-61-2 Chromatin/Epigenetic Histone Demethylase RG-6016 RG 6016 ORY-1001 (RG-6016) 2HCl ORY-1001 (RG-6016) ORY-1001 RG6016 ORY 1001 Inhibitor inhibitor inhibit