Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tecadenoson (CVT-510) is a selective agonist of A1 adenosine receptor.
説明 | Tecadenoson (CVT-510) is a selective agonist of A1 adenosine receptor. |
In vitro | Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41?nM) than to increase coronary conductance (EC50=200?nM) in the atrial-paced isolated heart. Tecadenoson shortens atrial (EC50=73?nM) but not the ventricular monophasic action potentials (MAP). At concentrations of Tecadenoson (40?nM) and diltiazem (1?μM) that induces equal prolongation of S-H interval (~10?ms), diltiazem, but not Tecadenoson, significantly decreases left ventricular developed pressure (LVP) and markedly increases coronary conductance [1]. |
In vivo | Intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval In atrial-paced anaesthetized guinea-pigs. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson (50 μg/kg) treatment induces a significant bradycardia (50% decrease in heart rate at 25 min) [1][2]. |
別名 | CVT-510 |
分子量 | 337.33 |
分子式 | C14H19N5O5 |
CAS No. | 204512-90-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 155 mg/mL (459.49 mM)
You can also refer to dose conversion for different animals. 詳細
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Tecadenoson 204512-90-3 GPCR/G Protein Neuroscience Adenosine Receptor Inhibitor CVT 510 P1 receptor CVT510 inhibit CVT-510 inhibitor