Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 15,500 | |||
25 mg | 在庫あり | ¥ 28,500 | |||
100 mg | 在庫あり | ¥ 76,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
ターゲット&IC50 | 5-HT3A:0.04 nM(Ki) |
In vitro | VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore. [1] |
分子量 | 262.74 |
分子式 | C13H15ClN4 |
CAS No. | 155584-74-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 26.3 mg/mL (100 mM)
DMSO: 26.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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VUF 10166 155584-74-0 GPCR/G Protein Neuroscience 5-HT Receptor 5-HT3A neurotransmission 5-HT3AB inhibit VUF-10166 5-HT3 receptor ligand 5-hydroxytryptamine Receptor Serotonin Receptor VUF10166 agonist Inhibitor inhibitor