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T0322 |
Fipexide
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Dopamine Receptor
,
AChR
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Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is... |
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T21995 |
XAP044
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GluR
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XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1]. |
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T9461 |
AZ194
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Sodium Channel
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CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor. |
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T6728 |
VUF 10166
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5-HT Receptor
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VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
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T11349 |
GABAA receptor agent 1
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GABA Receptor
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GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor. |
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T8333 |
Aurintricarboxylic acid
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ATA,NSC-4056,NSC4056,NSC 4056 |
Apoptosis
,
P2X Receptor
,
Influenza Virus
,
Topoisomerase
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Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. |
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T7823 |
IDRA-21
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GluR
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IDRA-21 is a positive AMPA receptor modulator. |
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T9409 |
Mesdopetam hemitartrate
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IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) |
Dopamine Receptor
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Mesdopetam hemitartrate (IRL790 hemitartrate) is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties. |
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T34399 |
Rovatirelin
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KPS-0373,S0373,S-0373,S 0373 |
AChE
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Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine an... |
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T7549 |
Talnetant
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SB 223412 |
Neurokinin receptor
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Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission |
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T69552 |
Suzetrigine
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VX-548 |
Sodium Channel
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Suzetrigine（VX-548） is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission. |
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T20828 |
Citalopram
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Cipram,Lu 10-171,Lu-10-171 Lu10-171 |
5-HT Receptor
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Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enant... |
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T60707 |
Quinupramine
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Quinupramine is an orally active antidepressant that shows antidepressant activity associated with the central serotonin system, but not with the β-adrenergic system. Quinupramine is able to penetrate into the CNS and af... |
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T26778 |
Besipirdine
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HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493 |
Sodium Channel
,
Adrenergic Receptor
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Besipirdine (HP 749 free base) is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine inhibits voltage-dependent sodium-potassium channels and inhibits biogeni... |
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T1279 |
Vilazodone
|
SB659746A,EMD 68843 |
5-HT Receptor
,
Serotonin Transporter
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Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from... |
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T2546 |
Pimozide
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R6238 |
Potassium Channel
,
Dopamine Receptor
,
Adrenergic Receptor
,
STAT
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Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby... |
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T26778L |
Besipirdine hydrochloride
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HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base) |
Adrenergic Receptor
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Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine hydrochloride inhibits voltage-dependent sodium-potassium channels and inhibit... |
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T16263 |
N6-Cyclopentyladenosine
|
UK-80882,CPA |
Adenosine Receptor
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N6-Cyclopentyladenosine (CPA) is a selective agonist of the adenosine A1 receptor and can be used to mimic the action of the adenosine A1 receptor, with Ki's of 2.3 nM, 790 nM, and 43 nM for human A1, A2A, and A3 recepto... |
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T25558 |
JNJ-55511118
|
JNJ 55511118 |
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JNJ-55511118 is a selective negative modulator of AMPA receptors containing TARP-γ8 (Ki: 26 nM). It had excellent pharmacokinetic properties. JNJ-55511118 exhibited a dose-dependent inhibition of neurotransmission within... |
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T27331 |
Flerobuterol HCl
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CRL-40996,CRL40996,CRL 40996,Flerobuterol hydrochloride |
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Flerobuterol is a β adrenergic receptor agonist potentially for the treatment of major depressive disorder. Flerobuterol enhances serotonergic neurotransmission. Flerobuterol acutely increases 5-HT synthesis, in part, th... |
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T26200 |
Somatostatin RC 102
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Somatostatin RC102,Somatostatin-RC-102,Somatostatin RC-102 |
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Somatostatin RC 102 is a peptide hormone. It regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release... |
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T78584 |
Prostaglandin D3
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PGD3 |
Prostaglandin Receptor
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Prostaglandin D3 (PGD3) functions as an inhibitor of platelet aggregation and modulates autonomic neurotransmission in humans [1]. |
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T79692 |
BChE-IN-19
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BChE-IN-19 (Compound 7b), a para-substituted indone derivative, exhibits potent inhibitory activity against butyryl cholinesterase (BChE) with an IC50 value of 0.04 μM. It enhances cholinergic neurotransmission and has p... |
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TP1732 |
Galanin (1-30), human
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Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Endogenous peptide with multiple endocrine, metabolic and behavioral effects. Has been sh... |
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T75944 |
Spadin TFA
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Spadin TFA, a natural peptide originating from a propeptide in blood, acts as a powerful TREK-1 channel inhibitor with an IC 50 of 10 nM. It boosts dorsal raphe nucleus 5-HT neurotransmission in mice, activates hippocamp... |
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T75916 |
Dynorphin A TFA
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Dynorphin A TFA, an endogenous opioid peptide, plays a role in inhibitory neurotransmission within the central nervous system (CNS). It acts as a highly potent kappa opioid receptor (KOR) agonist and also stimulates othe... |
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T78126 |
Dothiepin
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Dosulepin,Dothep |
Histamine Receptor
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Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. ... |
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T78827 |
CVN417
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CVN417 is an orally active antagonist of nAChR containing the α6 subunit, modulating phasic dopaminergic neurotransmission in an impulse-dependent fashion. It inhibits Ca(2+) efflux through nAChR subunits, displaying IC5... |
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TMIH-0159 |
Citalopram-d6
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Citalopram-d6 is a deuterated compound of Citalopram. Citalopram has a CAS number of 59729-33-8. Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine r... |
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T64672 |
Colivelin TFA
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Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activat... |
