| TN7060 |
Methyl oleanonate
|
|
PPAR
|
|
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties. |
| T1286 |
Vincamine
|
Angiopac,Oxybral,Devincan,Novicet,Equipur,Perval |
GPR
,
Others
|
|
Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders. |
| TN1055 |
Licochalcone E
|
|
TNF
,
Liver X Receptor
,
PPAR
|
|
Licochalcone E is a potential LXRβ agonist. |
| T15643 |
Kainic acid
|
|
Others
|
|
In the CNS, Kainic acid is an effective agonist at excitatory amino acid receptor subtypes. |
| T9114 |
β-Caryophyllene
|
(-)-(E)-Caryophyllene,(−)-β-caryophyllene,(−)-trans-Caryophyllene |
Cannabinoid Receptor
,
Endogenous Metabolite
|
|
β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist. |
| T23306 |
Salvinorin A
|
|
Opioid Receptor
|
|
Salvinorin A is a non-nitrogenous κ-opioid selective agonist. |
| TQ0203 |
Tafluprost
|
MK2452,AFP-168 |
Prostaglandin Receptor
|
|
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α. |
| T1683 |
Actriol
|
Epiestriol |
Glucocorticoid Receptor
|
|
Actriol (Epiestriol) is always used as Glucocorticoid Receptor agonist. |
| T8035 |
3'-Methoxyflavonol
|
|
NMU2R
|
|
3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R). |
| T12296 |
Oleoylethanolamide
|
N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide |
Endogenous Metabolite
,
PPAR
|
|
Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α. |
| T5805 |
Guvacoline hydrochloride
|
Norarecoline hydrochloride |
AChR
|
|
Guvacoline hydrochloride (Norarecoline hydrochloride) is a muscarinic agonist. |
| T8299 |
Dimethyl lithospermate B
|
dmLSB |
Sodium Channel
|
|
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. |
| T7974 |
Lynestrenol
|
|
Progesterone Receptor
|
|
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist |
| T3362 |
Eupatilin
|
NSC 122413 |
PPAR
,
Autophagy
|
|
Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity. |
| T3668 |
Galangin
|
Norizalpinin,3,5,7-Trihydroxyflavone |
ERK
,
P450
,
NF-κB
,
Autophagy
|
|
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. |
| T0453 |
Phenylephrine hydrochloride
|
NCI-c55641,Phenylephrine HCl,(R)-(-)-Phenylephrine hydrochloride |
Endogenous Metabolite
,
Adrenergic Receptor
|
|
Phenylephrine hydrochloride (NCI-c55641) is a selective agonist of the α1-adrenergic receptor. |
| TN1927 |
Methyl Kakuol
|
1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one |
TRP/TRPV Channel
|
|
Methyl Kakuol is an agonist of TRPA1 with an EC50 of 0.27 µM and can be used in studies about acting as an active ingredient in MBST constituent Asiasari Radix. |
| T7117 |
Sapropterin dihydrochloride
|
Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,6R-BH4 dihydrochloride |
Hydroxylase
|
|
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU. |
| T1704 |
Diosmetin
|
Luteolin 4-methyl ether |
P450
,
Trk receptor
|
|
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist. |
| T2870 |
Matrine
|
Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine |
Mitophagy
,
Ferroptosis
,
Opioid Receptor
,
Autophagy
|
|
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. |
| T12095 |
Monomethyl fumarate
|
|
GPR
,
Drug Metabolite
|
|
Monomethyl fumarate is a potent agonist of GPR109A . |
| T17310 |
Phenylephrine
|
L-Phenylephrine,(R)-(-)-Phenylephrine |
Adrenergic Receptor
|
|
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively). |
| T6519 |
Gramine
|
NSC 16892,Donaxine |
Adiponectin receptor
,
Reverse Transcriptase
,
Adrenergic Receptor
|
|
Gramine (Donaxine), a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is als... |
| T0804 |
Pilocarpine Hydrochloride
|
NSC 5746 HCl,Pilocarpine HCl,(+)-Pilocarpine hydrochloride |
AChR
|
|
Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy. |
| T7224 |
Anabasine
|
(S)-Anabasine,(-)-Anabasine |
AChR
|
|
Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco. Anabasine is a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. Anabasine depolarizes TE671 cells endogenously expres... |
| T6688 |
Synephrine hydrochloride
|
Oxedrine hydrochloride,Synephrine HCl |
Endogenous Metabolite
,
Adrenergic Receptor
|
|
Synephrine hydrochloride (Oxedrine hydrochloride) is an agonist that acts on sympathomimetic α-adrenergic receptor (AR). |
| T6662 |
Scopine
|
6,7-Epoxytropine |
Adrenergic Receptor
|
|
Scopine (6,7-Epoxytropine), the metabolite of anisodine, is an α1-adrenergic receptor agonist used in the therapy of acute circulatory shock. |
| T2198 |
Arecoline hydrobromide
|
Arecoline HBr,Arecoline bromide |
AChR
|
|
Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist. |
| T37709 |
2,2,2-Trichloroethanol
|
|
Potassium Channel
,
Endogenous Metabolite
|
|
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
2,2,2-trichloroethanol activates a nonclassical ... |
| T3325 |
Liquiritigenin
|
4',7-Dihydroxyflavanone |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
|
|
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist. |
| TN1296 |
5-Feruloylquinic acid
|
5-O-Feruloylquinic acid,5-FQA |
Tyrosinase
,
Sirtuin
|
|
5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated with aging. |
| T0268 |
Lobeline hydrochloride
|
α-Lobeline hydrochloride,L-Lobeline hydrochloride |
AChR
|
|
Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes. |
| T1352 |
ATP disodium salt
|
Adenosine 5'-triphosphate disodium salt,ATP,ATP disodium,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate |
P2X Receptor
,
Endogenous Metabolite
|
|
ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist. |
| TQ0274 |
27-Hydroxycholesterol
|
25(R)-27-hydroxy Cholesterol |
Estrogen/progestogen Receptor
,
Liver X Receptor
|
|
|
| T13092 |
Tauro-Obeticholic acid
|
|
FXR
|
|
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). |
| TQ0279 |
Ibotenic acid
|
(+/-)-Ibotenic acid,DL-Ibotenic acid,Ibotenate,(RS)-Ibotenic acid |
NMDAR
|
|
Ibotenic acid (RS-42358-197) has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors. |
| T1231 |
Pilocarpine nitrate
|
Pilagan,Pilofrin |
AChR
|
|
Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. |
| T1287 |
Synephrine
|
Oxedrine |
Endogenous Metabolite
,
Adrenergic Receptor
|
|
Synephrine (Oxedrine) is sympathetic alpha-adrenergic agonist used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma. |
| TN1248 |
3-Epioleanolic acid
|
|
AChR
|
|
3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle. |
| T13456 |
(S)-Willardiine
|
(-)-Willardiine,L-willardiine,Willardiine |
iGluR
|
|
(S)-Willardiine (L-willardiine) is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM). |
| T8895 |
Altenusin
|
|
FXR
|
|
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM. |
| T9719 |
3-Hydroxyoctanoic Acid
|
|
GPR
|
|
3-Hydroxyoctanoic Acid is one of the hydroxy-carboxylic acids (HCAs) that serve as intermediates of energy metabolism. It is an agonist of the orphan receptor GPR109B. |
| T0505 |
Methyldopa
|
L-(-)-α-Methyldopa,MK-351 |
Dopamine Receptor
,
Adrenergic Receptor
|
|
Methyldopa (MK-351), an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic. |
| T3000 |
Magnolol
|
NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol |
NF-κB
,
Retinoid Receptor
,
Antibacterial
,
PPAR
,
p53
,
Autophagy
|
|
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation. |
| T2209 |
Serotonin hydrochloride
|
5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride |
5-HT Receptor
,
Endogenous Metabolite
,
Transferase
|
|
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). |
| T4885 |
(-)-Aspartic acid
|
(R)-Aspartic acid,Asp,D-(-)-Aspartic acid,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid |
Endogenous Metabolite
,
NMDAR
,
iGluR
|
|
(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA receptor. |
| T60237 |
L-Cysteine S-sulfate
|
S-Sulfo-L-cysteine |
NMDAR
|
|
L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1]. |
| T6608 |
NMDA
|
N-Methyl-D-aspartic acid |
Endogenous Metabolite
,
NMDAR
,
iGluR
|
|
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors. |
| T4096 |
Quinolinic acid
|
pyridine-2,3-dicarboxylic acid,QUIN |
Endogenous Metabolite
,
NMDAR
,
iGluR
|
|
Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway. |
| T2177 |
Kaempferol
|
Kempferol,Robigenin |
Apoptosis
,
Estrogen Receptor/ERR
,
Mitophagy
,
Estrogen/progestogen Receptor
,
HIV Protease
,
Endogenous Metabolite
,
Parasite
,
Autophagy
|
|
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities. |
