Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,000 | |||
2 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 85,000 | |||
100 mg | 在庫あり | ¥ 126,000 |
説明 | Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest. |
ターゲット&IC50 | PDE3:1.1 μM |
別名 | OPC-8212, Arkin, Piteranometozine |
分子量 | 395.45 |
分子式 | C22H25N3O4 |
CAS No. | 81840-15-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.95 mg/mL (9.99 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Vesnarinone 81840-15-5 Metabolism Microbiology/Virology Proteases/Proteasome PDE HIV Protease phosphodiesterase 3 OPC8212 Inhibitor OSC5 oral activity OSC4 OSC3 positive inotropic activity heart failure OPC-8212 OPC 8212 Arkin inhibit Piteranometozine Phosphodiesterase (PDE) inhibitor