Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 29,000 | |||
5 mg | 在庫あり | ¥ 91,500 | |||
10 mg | 在庫あり | ¥ 137,000 | |||
25 mg | 在庫あり | ¥ 214,500 | |||
50 mg | 在庫あり | ¥ 289,500 | |||
100 mg | 在庫あり | ¥ 388,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 121,000 |
説明 | Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity. |
ターゲット&IC50 | HIV-1 (isolates):66-410 nM, HIV-1 (isolates):8 pM(Ki ) |
In vitro | Tipranavir (PNU-140690) inhibits the enzymatic activity of HIV-1 protease, blocks the dimerization of protease subunits, and exerts potent activity against a wide spectrum of wild-type and multi-PI-resistant HIV-1 variants.[1] |
In vivo |
Tipranavir (5 mg/kg ; mouse model): CLtot was 0.17 ± 0.10 L/h/kg, Vss was 0.51 ± 0.14 L/kg, and t1/2 was 5.4 ±0. 3h.[4] Tipranavir (10 mg/kg ; oral ; rats): got the result of F was 30% compared to 5 mg/kg tipranavir dosing.[4] |
別名 | PNU-140690 |
分子量 | 602.66 |
分子式 | C31H33F3N2O5S |
CAS No. | 174484-41-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 45.0 mg/mL (74.7 mM)
DMSO: 180.0 mg/mL (298.7 mM ), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tipranavir 174484-41-4 Microbiology/Virology Proteases/Proteasome SARS-CoV HIV Protease PNU 140690 PNU140690 PNU-140690 Inhibitor inhibitor inhibit