Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.
説明 | WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer. |
In vitro | WITHAFERIN A,potently inhibits NFkappaB activation by preventing the tumor necrosis factor-induced activation of IkappaB kinase beta via a thioalkylation-sensitive redox mechanism. |
In vivo | WITHAFERIN A Displays Anti-inflammatory Properties in Vivo—Because NFκB is a critical player in the inflammatory signaling pathway and because WITHAFERIN A inhibits NFκB activation. |
細胞研究 | L929sA cells were co-treated with WITHAFERIN A and DTT for 1 h, and then TNF-induced NFκB activation was examined. |
動物実験 | Mice are injected subcutaneously with zymosan in the footpad, and swelling is determined at several time points after the injection. Pretreatment with WITHAFERIN A(intraperitoneal) was performed to evaluate anti-inflammatory effects, whereas DEX (intraperitoneal) was chosen as a positive control. the mean of the differences between the zymosan-treated and untreated footpad for all the three groups. Both DEX. |
植物由来 |
分子量 | 470.6 |
分子式 | C28H38O6 |
CAS No. | 5119-48-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (58.44 mM)
You can also refer to dose conversion for different animals. 詳細
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WITHAFERIN A 5119-48-2 Apoptosis NF-Κb NF-κB Ferroptosis Nuclear factor-κB Inhibitor Nuclear factor-kappaB inhibit inhibitor