Powder: -20°C for 3 years | In solvent: -80°C for 1 year
XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).
説明 | XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM). |
ターゲット&IC50 | RORγ:(kd)380 nM , RORγ:30 nM |
In vitro | XY101 effectively inhibits cell growth, colony formation and expression of androgen receptor (AR), AR-V7 and prostate specific antigen (PSA)[1]. |
In vivo | XY101 demonstrates substantial antitumor effects, including inhibition of tumor growth, throughout the treatment period and is well-tolerated, evidenced by the absence of significant body weight loss[1]. |
分子量 | 563.48 |
分子式 | C25H20F7NO4S |
CAS No. | 2349368-16-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (399.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
XY101 2349368-16-5 Metabolism ROR XY-101 XY 101 Inhibitor inhibitor inhibit