Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.
説明 | BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4. |
In vitro | BIMU 8 (0.003-0.1 µM) increases excitatory postsynaptic potentials amplitude without changing the membrane potential of any neuron in myenteric neurons of guinea pig ileum[1]. |
In vivo | BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception. In mice, BIMU 8 (10 μg; i.c.v) which is largely ineffective by parenteral routes induces antinociception[2]. |
分子量 | 378.9 |
分子式 | C19H27ClN4O2 |
CAS No. | 134296-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (118.76 mM)
You can also refer to dose conversion for different animals. 詳細
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BIMU 8 134296-40-5 GPCR/G Protein Neuroscience 5-HT Receptor inhibit 5-hydroxytryptamine Receptor BIMU-8 Inhibitor antidepressant Serotonin Receptor BIMU8 antinociception 5-HT4 EPSP inhibitor