Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-599626 Hydrochloride (AC480 Hydrochloride) is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 Hydrochloride inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,500 | |||
5 mg | 在庫あり | ¥ 20,000 | |||
10 mg | 在庫あり | ¥ 30,500 | |||
25 mg | 在庫あり | ¥ 58,000 | |||
50 mg | 在庫あり | ¥ 102,500 | |||
100 mg | 在庫あり | ¥ 151,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 25,000 |
説明 | BMS-599626 Hydrochloride (AC480 Hydrochloride) is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 Hydrochloride inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. |
ターゲット&IC50 | HER1:22 nM, HER2:32nM, HER4:190 nM |
In vitro | BMS-599626 Hydrochloride abrogates HER1 and HER2 signaling and inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC50s in the range of 0.24 to 1 μM.In GEO cells, HER1 phosphorylation is stimulated by treatment with EGF and is inhibited by BMS-599626 Hydrochloride (IC50=0. 75 μM).There is also nearly complete inhibition of EGF-dependent MAPK (0. 8 μM) but only partial inhibition of AKT signaling.The latter likely reflects the activation of AKT by multiple upstream signals.Treatment of N87 cells with BMS-599626 Hydrochloride leads to the inhibition of HER2 (0. 38 μM), which is expressed to a high level because of gene amplification, as well as MAPK and AKT phosphorylation (0.35 μM for both) [1]. |
In vivo | BMS-599626 Hydrochloride given before and during irradiation improved the radioresponse of HN5 tumors in vivo [2]. |
別名 | AC480 Hydrochloride |
分子量 | 567.01 |
分子式 | C27H28ClFN8O3 |
CAS No. | 873837-23-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (158.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BMS-599626 Hydrochloride 873837-23-1 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors HER AC 480 Hydrochloride BMS599626 Hydrochloride AC480 Hydrochloride AC-480 Hydrochloride BMS 599626 Hydrochloride Inhibitor inhibitor inhibit