Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 75,500 | |||
10 mg | 在庫あり | ¥ 129,500 | |||
25 mg | 在庫あり | ¥ 257,000 | |||
50 mg | 在庫あり | ¥ 420,000 | |||
100 mg | 在庫あり | ¥ 663,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 83,500 |
説明 | EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs. |
ターゲット&IC50 | ALK5:4.83 nM (IC50), p38α:1.5 μM (IC50) |
In vitro | In vitro, EW-7195 efficiently inhibits the epithelial-to-mesenchymal transition (EMT), motility, and invasiveness of breast cancer cells. Following a 1.5-hour treatment at concentrations of 0.5-1 µM, EW-7195 effectively blocks TGF-β1-induced phosphorylation of Smad2, subsequently preventing the nuclear translocation of Smad2/3. Additionally, EW-7195 hinders TGF-β1-induced mesenchymal morphology and transcriptional activation[1]. |
In vivo | In both 4T1 orthotopic xenograft and MMTV/cNeu transgenic mice, EW7195 (40 mg/kg; intraperitoneal; three times a week for 3/2.5 weeks) inhibits the development of lung metastasis[1]. |
分子量 | 406.44 |
分子式 | C23H18N8 |
CAS No. | 1352609-28-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (98.42 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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EW-7195 1352609-28-9 Angiogenesis Stem Cells Tyrosine Kinase/Adaptors TGF-beta/Smad ALK EW 7195 EW7195 Inhibitor inhibitor inhibit