Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 8,500 | |||
10 mg | 在庫あり | ¥ 12,000 | |||
25 mg | 在庫あり | ¥ 18,000 | |||
50 mg | 在庫あり | ¥ 22,500 | |||
100 mg | 在庫あり | ¥ 37,500 | |||
500 mg | 在庫あり | ¥ 90,500 |
説明 | Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM) |
ターゲット&IC50 | ALK:1.9 nM |
In vivo | Alectinib hydrochloride(CH5424802), a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo |
動物実験 | Animal Model:SCID or nude mice bearing NCI-H2228 cells. Dosage:0.2 mg/kg, 0.6 mg/kg, 2 mg/kg, 6 mg/kg, 20 mg/kg. Administration:Oral administration; once daily; for 11 days |
別名 | CH5424802 (Hydrochloride), AF-802 (Hydrochloride), RO5424802 (Hydrochloride) |
分子量 | 519.08 |
分子式 | C30H35ClN4O2 |
CAS No. | 1256589-74-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.25 mg/mL (12.04 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Alectinib hydrochloride 1256589-74-8 Angiogenesis Tyrosine Kinase/Adaptors ALK Cluster of differentiation 246 CH-5424802 RO 5424802 AF-802 Alectinib Hydrochloride inhibit Inhibitor CH5424802 (Hydrochloride) AF802 Alectinib RO5424802 RO-5424802 CH 5424802 ALK tyrosine kinase receptor AF-802 (Hydrochloride) RO5424802 (Hydrochloride) Anaplastic lymphoma kinase CD246 CH5424802 Anaplastic lymphoma kinase (ALK) AF 802 inhibitor