Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hydrocotarnine is an inhibitor of Cbl.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,000 | |||
5 mg | 在庫あり | ¥ 39,000 | |||
10 mg | 在庫あり | ¥ 60,500 | |||
25 mg | 在庫あり | ¥ 121,500 | |||
50 mg | 在庫あり | ¥ 176,500 | |||
100 mg | 在庫あり | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 36,000 |
説明 | hydrocotarnine is an inhibitor of Cbl. |
In vivo | In vivo, inhibition of Cbl with an analgesic drug, hydrocotarnine, increases inflammasome-mediated IL-18 secretion in the colon, and protects mice from dextran sulphate sodium-induced colitis. Together, our novel findings provide new insights into the role of the SFK-Cbl axis in suppressing NLRP3 inflammasome activation and identify a novel clinical utility of hydrocortanine for disease treatment[2]. |
分子量 | 221.25 |
分子式 | C12H15NO3 |
CAS No. | 550-10-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (248.59 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
hydrocotarnine 550-10-7 Others E3 ligating enzyme IL-18 NLRP3 E1/E2/E3 Enzyme inflammasome activation IL-1β Ubiquitin conjugating enzyme E1 activating enzyme inhibit Ubiquitin activating enzyme GLUT1 E2 conjugating enzyme cancer pain Ubiquitin ligase Inhibitor glycolytic metabolism glycolytic capacity cellular glucose uptake inhibitor