Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 20,500 | |||
10 mg | 在庫あり | ¥ 29,500 | |||
25 mg | 在庫あり | ¥ 50,500 | |||
50 mg | 在庫あり | ¥ 75,000 | |||
100 mg | 在庫あり | ¥ 111,500 | |||
500 mg | 在庫あり | ¥ 243,500 |
説明 | JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells. |
ターゲット&IC50 | JAK2:22.86 μg/mL |
In vitro | The treatment of JAK2-IN-6 (Compound B2; 6.3-50 μg/mL; 48 hours) demonstrates significant antiproliferative activity against PC-9, H1975, and PANC-1 cell lines. The IC50 values for PC-9, H1975, and PANC-1 cell lines are 18.1 μg/mL, 58.3 μg/mL, and 40.6 μg/mL, respectively [1]. |
別名 | JAK2-IN-6 |
分子量 | 335.83 |
分子式 | C14H10ClN3OS2 |
CAS No. | 353512-04-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 54.0 mg/mL (160.8 mM), when pH is adjusted to 5 with HCl. Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JAK2-IN-6 353512-04-6 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK JAK-2-IN-6 JAK2IN6 JAK2 IN 6 Inhibitor inhibitor inhibit