Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Salvianolic acid B is a water-soluble antioxidant from Salvia extract. Salvianolic acid B plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect.
説明 | Salvianolic acid B is a water-soluble antioxidant from Salvia extract. Salvianolic acid B plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect. |
In vitro |
METHODS: Rat brain microvascular endothelial cells rCMECs were pretreated with Salvianolic acid B (0-100 µM) for 30 min and incubated with H2O2 (200 µM) for 12 h. Apoptosis was detected by TUNEL assay. RESULTS: Salvianolic acid B pretreatment dose-dependently reduced H2O2-induced apoptosis. [1] METHODS: Mouse primary hepatic stellate cell HSCs were treated with Salvianolic acid B (10 µmol/L) for 48 h. Cell proliferation was detected by MTT assay. RESULTS: Cells treated with Salvianolic acid B significantly reduced cell proliferation at 48 h. [2] |
In vivo | The administration of Salvianolic acid B (10 mg/kg) significantly ameliorates the memory impairment induced by the Aβ25-35 peptide in the passive avoidance task (P<0.05). Additionally, Salvianolic acid B treatment reduces the number of activated microglia and astrocytes observed during the inflammatory reaction following the administration of the Aβ25-35 peptide. Furthermore, Salvianolic acid B markedly reduces the expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as thiobarbituric acid reactive substances, which are increased by the administration of the Aβ25-35 peptide. Moreover, Salvianolic acid B administration significantly rescues the Aβ25-35 peptide-induced decrease in choline acetyltransferase and brain-derived neurotrophic factor protein levels[2]. |
別名 | lithospermic acid B, Dan Shen Suan B |
分子量 | 718.61 |
分子式 | C36H30O16 |
CAS No. | 121521-90-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Saline: 718.61 mg/mL (34.79 mM)
DMSO: 50 mg/mL (69.58 mM)
You can also refer to dose conversion for different animals. 詳細
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Salvianolic acid B 121521-90-2 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin 115939-25-8 Inhibitor inhibit lithospermic acid B Dan Shen Suan B inhibitor