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T39924 |
NF-κΒ activator 2
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|
NF-κB
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NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyo... |
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T13553 |
Arimoclomol
|
BRX-220 free base |
HSP
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Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS). |
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T60507 |
Utreloxastat
|
EPI 857,PTC857 |
Lipoxygenase
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Utreloxastat (PTC857) is a novel 15-lipoxygenase inhibitor that can be used to study amyotrophic lateral sclerosis
. |
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T60120 |
SOD1-Derlin-1 inhibitor 56-59
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Others
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SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research. |
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T0349 |
Riluzole
|
PK 26124,RP-54274 |
GABA Receptor
,
Sodium Channel
,
NMDAR
|
|
Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. |
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T21995 |
XAP044
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GluR
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XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1]. |
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T60108 |
PDGFR Tyrosine Kinase Inhibitor III
|
PDGF Receptor Tyrosine Kinase Inhibitor III |
PDGFR
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|
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF... |
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T60119 |
SOD1-Derlin-1 inhibitor-1
|
SOD1-Derlin-1 Inhibitor 56-20 |
Others
|
|
SOD1-Derlin-1 inhibitor-1 (SOD1-Derlin-1 Inhibitor 56-20) (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1 G93A -Derlin-1 complex with an IC 50 value of 7.11 μM. SOD1... |
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T77484 |
Atibuclimab
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|
TNF
|
|
Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region. Atibuclimab can be used to treat amyotrophic lateral sclerosis. Atibuclimab reduces LPS-indu... |
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T14390L |
(2R,3S)-Azelaprag
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|
Apelin receptor
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(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 µM.(2R,3S)-N-(4-(... |
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T35689 |
MTP 131 acetate
|
|
Others
|
|
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T31978 |
GM-608
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GM-606,GM-607,GM-604,GM-603,GM-605,GM-602 |
|
|
GM-604(alirinetide) is a potential treatment for amyotrophic lateral sclerosis and ischemic stroke. |
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T24814 |
Sortin2
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Sortin-2,Sortin 2 |
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|
Sortin2 is a sorting inhibitor that acts upstream from the morphological marker of lateral root primordium formation, the mitotic activity. |
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T35135 |
WN1316
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WN 1316,WN-1316 |
|
|
WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS). |
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T25852 |
Naxillin
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|
|
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Naxillin is the first non-auxin-like molecule that promotes root branching which acts as a specific lateral root development modulator. |
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T70892 |
K812
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|
|
|
K812 is an ASK1-specific inhibitor discovered to prolong survival in a mouse model of amyotrophic lateral sclerosis. |
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T11214 |
EPI-589
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Others
|
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EPI-589, a quinone derivative and oxidoreductase enzyme inhibitor, is considered safe and well tolerated, showing promise for the treatment of amyotrophic lateral sclerosis (ALS). |
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T39498 |
Tofersen
|
BIIB067,ISIS-SOD1Rx |
|
|
Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compoun... |
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T70893 |
K811
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|
|
|
K811 is an ASK1-specific inhibitor that prolongs survival in a mouse model of amyotrophic lateral sclerosis. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpress... |
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T81372 |
Proteasome-activating peptide 1
|
|
|
|
Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m... |
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T81580 |
Ozanezumab
|
GSK1223249 |
|
|
Ozanezumab (GSK1223249) is a monoclonal antibody targeting Nogo-A (neurite outgrowth inhibitor A). It is utilized in research related to amyotrophic lateral sclerosis (ALS) and multiple sclerosis [1]. |
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T61128 |
C-ABL-IN-2
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|
|
|
C-ABL-IN-2 is a highly effective inhibitor of the c-Abl protein, which plays a significant role in the development of several diseases, including cancer. This compound exhibits promise for investigating neurodegenerative... |
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T82704 |
CMB-087229
|
|
|
|
CMB-087229 is an inhibitor of mutant superoxide dismutase 1 (SOD1) protein aggregation, exhibiting an IC50 of 67 nM, and holds potential for use in amyotrophic lateral sclerosis research [1]. |
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T72959 |
NUCC-0000323
|
|
|
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NUCC-0000323 is a potent inhibitor of superoxide dismutase 1 (SOD1), effectively suppressing SOD1 expression. This compound has applications in amyotrophic lateral sclerosis (ALS) research. |
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T61546 |
C-ABL-IN-3
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|
|
|
c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer [1]. The ac... |
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T82560 |
Di-Ellipticine-RIBOTAC
|
|
PROTACs
|
|
Di-Ellipticine-RIBOTAC is a bifunctional small molecule that effectively diminishes the r(G4C2) repeat expansion associated with c9ALS/FTD both in vitro and in vivo, showcasing therapeutic potential in amyotrophic latera... |
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TP1542 |
26Rfa, Hypothalamic Peptide, human
|
|
|
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This human neuropeptide of the RFamide peptide family with orexigenic activity may be also involved in the control of feeding behavior. The 26RFa gene is exclusively expressed in the ventromedial hypothalamic nucleus and... |
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T78603 |
Sotuletinib dihydrochloride
|
BLZ945 dihydrochloride |
c-Fms
|
|
Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM. It promotes apoptosis in tumor cells and significantly restricts... |
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T73117 |
ROCK2-IN-5
|
|
|
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ROCK2-IN-5, a compound integrating structural elements from the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids, exhibits a favorable multitarget profile and tolerability. It shows potential ... |
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T37608 |
Riluzole-13C,15N2
|
Riluzole-13C,15N2 |
|
|
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic... |
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T76243 |
Proteasome-activating peptide 1 TFA
|
|
|
|
Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,... |
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T60966 |
UCPH-102
|
|
|
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UCPH-102 can be used in Alzheimer’s disease, amyotrophic lateral sclerosis, chronic pain and obsessive compulsive disorder studies with good blood-brain permeability. UCPH-102 is a highly selective inhibitor of EAAT1 wit... |
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T60953 |
BSc5367
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|
|
|
BSc5367 is a potent inhibitor for the Nek1 kinase domain with an IC50 value of 11.5 nM. Nek1 is a NIMA-related protein kinase that crucially involved in cell cycle regulation, DNA repair and microtubule regulation. The N... |
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T36499 |
CuATSM
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|
|
|
The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding ... |
|
TMIH-0552 |
Tauroursodeoxycholic Acid-d4 Sodium Salt
|
|
|
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Tauroursodeoxycholic Acid-d4 Sodium Salt is a deuterated compound of Tauroursodeoxycholic Acid Sodium Salt. Tauroursodeoxycholic Acid Sodium Salt has a CAS number of 14605-22-2. Tauroursodeoxycholate, also known as ursod... |
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T38218 |
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
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1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid in biological membranes containing stearic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively. It has been used to study the organiza... |
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T38286 |
C26 Sphingomyelin (d18:1/26:0)
|
C26 Sphingomyelin (d18:1/26:0) |
|
|
C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory co... |
