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T39924 |
NF-κΒ activator 2
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NF-κB
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NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyo... |
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T13553 |
Arimoclomol
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BRX-220 free base |
HSP
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Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS). |
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T60507 |
Utreloxastat
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EPI 857,PTC857 |
Lipoxygenase
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Utreloxastat (PTC857) is a novel 15-lipoxygenase inhibitor that can be used to study amyotrophic lateral sclerosis
. |
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T60120 |
SOD1-Derlin-1 inhibitor 56-59
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Others
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SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research. |
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T0349 |
Riluzole
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PK 26124,RP-54274 |
GABA Receptor
,
Sodium Channel
,
NMDAR
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Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. |
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T60108 |
PDGFR Tyrosine Kinase Inhibitor III
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PDGF Receptor Tyrosine Kinase Inhibitor III |
PDGFR
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PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF... |
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T60119 |
SOD1-Derlin-1 inhibitor-1
|
SOD1-Derlin-1 Inhibitor 56-20 |
Others
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SOD1-Derlin-1 inhibitor-1 (SOD1-Derlin-1 Inhibitor 56-20) (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1 G93A -Derlin-1 complex with an IC 50 value of 7.11 μM. SOD1... |
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T77484 |
Atibuclimab
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TNF
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Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region. Atibuclimab can be used to treat amyotrophic lateral sclerosis. Atibuclimab reduces LPS-indu... |
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T14390L |
(2R,3S)-Azelaprag
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Apelin receptor
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(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 µM.(2R,3S)-N-(4-(... |
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T35689 |
MTP 131 acetate
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Others
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MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T31978 |
GM-608
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GM-606,GM-607,GM-604,GM-603,GM-605,GM-602 |
|
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GM-604(alirinetide) is a potential treatment for amyotrophic lateral sclerosis and ischemic stroke. |
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T70892 |
K812
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|
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K812 is an ASK1-specific inhibitor discovered to prolong survival in a mouse model of amyotrophic lateral sclerosis. |
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T35135 |
WN1316
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WN 1316,WN-1316 |
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WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS). |
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T11214 |
EPI-589
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Others
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EPI-589, a quinone derivative and oxidoreductase enzyme inhibitor, is considered safe and well tolerated, showing promise for the treatment of amyotrophic lateral sclerosis (ALS). |
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T39498 |
Tofersen
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BIIB067,ISIS-SOD1Rx |
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Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compoun... |
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T81372 |
Proteasome-activating peptide 1
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|
|
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Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m... |
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T81580 |
Ozanezumab
|
GSK1223249 |
|
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Ozanezumab (GSK1223249) is a monoclonal antibody targeting Nogo-A (neurite outgrowth inhibitor A). It is utilized in research related to amyotrophic lateral sclerosis (ALS) and multiple sclerosis [1]. |
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T70893 |
K811
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|
|
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K811 is an ASK1-specific inhibitor that prolongs survival in a mouse model of amyotrophic lateral sclerosis. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpress... |
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T61128 |
C-ABL-IN-2
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|
|
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C-ABL-IN-2 is a highly effective inhibitor of the c-Abl protein, which plays a significant role in the development of several diseases, including cancer. This compound exhibits promise for investigating neurodegenerative... |
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T72959 |
NUCC-0000323
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|
|
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NUCC-0000323 is a potent inhibitor of superoxide dismutase 1 (SOD1), effectively suppressing SOD1 expression. This compound has applications in amyotrophic lateral sclerosis (ALS) research. |
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T61546 |
C-ABL-IN-3
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|
|
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c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer [1]. The ac... |
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T82704 |
CMB-087229
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|
|
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CMB-087229 is an inhibitor of mutant superoxide dismutase 1 (SOD1) protein aggregation, exhibiting an IC50 of 67 nM, and holds potential for use in amyotrophic lateral sclerosis research [1]. |
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T82560 |
Di-Ellipticine-RIBOTAC
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PROTACs
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Di-Ellipticine-RIBOTAC is a bifunctional small molecule that effectively diminishes the r(G4C2) repeat expansion associated with c9ALS/FTD both in vitro and in vivo, showcasing therapeutic potential in amyotrophic latera... |
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T78603 |
Sotuletinib dihydrochloride
|
BLZ945 dihydrochloride |
c-Fms
|
|
Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM. It promotes apoptosis in tumor cells and significantly restricts... |
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T37608 |
Riluzole-13C,15N2
|
Riluzole-13C,15N2 |
|
|
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic... |
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T76243 |
Proteasome-activating peptide 1 TFA
|
|
|
|
Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,... |
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T73117 |
ROCK2-IN-5
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|
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ROCK2-IN-5, a compound integrating structural elements from the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids, exhibits a favorable multitarget profile and tolerability. It shows potential ... |
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T60966 |
UCPH-102
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|
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UCPH-102 can be used in Alzheimer’s disease, amyotrophic lateral sclerosis, chronic pain and obsessive compulsive disorder studies with good blood-brain permeability. UCPH-102 is a highly selective inhibitor of EAAT1 wit... |
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T60953 |
BSc5367
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|
|
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BSc5367 is a potent inhibitor for the Nek1 kinase domain with an IC50 value of 11.5 nM. Nek1 is a NIMA-related protein kinase that crucially involved in cell cycle regulation, DNA repair and microtubule regulation. The N... |
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T36499 |
CuATSM
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The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding ... |
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TMIH-0552 |
Tauroursodeoxycholic Acid-d4 Sodium Salt
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Tauroursodeoxycholic Acid-d4 Sodium Salt is a deuterated compound of Tauroursodeoxycholic Acid Sodium Salt. Tauroursodeoxycholic Acid Sodium Salt has a CAS number of 14605-22-2. Tauroursodeoxycholate, also known as ursod... |
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T38218 |
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
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1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid in biological membranes containing stearic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively. It has been used to study the organiza... |
