store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 41,000 | |||
5 mg | 在庫あり | ¥ 100,500 | |||
10 mg | 在庫あり | ¥ 148,500 | |||
25 mg | 在庫あり | ¥ 226,500 | |||
50 mg | 在庫あり | ¥ 317,000 | |||
100 mg | 在庫あり | ¥ 427,000 |
説明 | OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket. |
ターゲット&IC50 | ALK2:37 nM (Kd), ALK2:47 nM (IC50), RIPK2:5.3 nM (IC50), ALK2 (R206H):22 nM (IC50) |
In vitro |
OD36 shows activity against ALK1 (KD=90 nM).[2] OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation.[2] OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5.[2] OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).[2] |
In vivo | OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression. OD36 alleviates inflammation in an acute peritonitis mice model.[3] |
別名 | OD 36, OD 36 hydrochloride, OD-36 |
分子量 | 330.77 |
分子式 | C16H15ClN4O2 |
CAS No. | 1638644-62-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (75.58 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
OD36 1638644-62-8 Angiogenesis Apoptosis NF-Κb Tyrosine Kinase/Adaptors ALK RIP kinase OD 36 OD36 Hydrochloride OD 36 Hydrochloride OD 36 hydrochloride OD-36 Hydrochloride OD-36 Inhibitor inhibitor inhibit