Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduced L-type Ca currents (I) with an IC of 0.24 μM, and against T-type Ca currents (I) with an IC of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 17,500 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 60,000 | |||
25 mg | 在庫あり | ¥ 116,500 | |||
50 mg | 在庫あり | ¥ 158,500 | |||
100 mg | 在庫あり | ¥ 225,500 | |||
500 mg | 在庫あり | ¥ 452,500 |
説明 | Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduced L-type Ca currents (I) with an IC of 0.24 μM, and against T-type Ca currents (I) with an IC of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs. |
ターゲット&IC50 | I(CaL):0.24 µM |
In vitro | In aortic rings, Oxodipine (10(-11)-10(-6) M) inhibited in a concentration-dependent manner the contractions induced by high K+ (IC50 = 9.0 +/- 4.0 x 10(-10) M) or by Ca2+ in high K+ solution (IC50 = 6.2 +/- 2.4 x 10(-9) M). In mesenteric resistance vessels, Oxodipine inhibited the contractions induced by high K+(IC50 = 5.2 +/- 3.1 x 10(-10)).[4] |
In vivo | Oxodipine (5, 20, and 50 μg/kg; anesthetized dogs), a new dihydropyridine calcium channel blocker, ineffective at 5 μg/kg, whereas doses of 20 and 50 μg/kg of oxodipine elicited a decrease in blood pressure with no change in heart rate. These results suggest that, in contrast to other first-generation dihydropyridines, oxodipine exerts a relatively specific action on blood vessels without significant intrinsic negative chronotropic properties in anesthetized sinoaortic-denervated dogs.[4] |
分子量 | 359.37 |
分子式 | C19H21NO6 |
CAS No. | 90729-41-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (153.05 mM)
You can also refer to dose conversion for different animals. 詳細
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Oxodipine 90729-41-2 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor inhibitor inhibit